Table 4.

Adjusted ORs (95% CIs) for baseline tertiles of plasma IGF biomarkers and nonadvanced and advanced colorectal adenoma recurrence

BiomarkernNonadvanced recurrenceAdjusted* OR (95% CI)Advanced recurrenceAdjusted* OR (95% CI)
IGF-I (mean, ng/mL)
    68.0 ± 22.8100361.00231.00
    116.4 ± 12.299310.58 (0.29-1.14)170.44 (0.19-1.02)
    176.3 ± 35.599320.56 (0.29-1.10)120.34 (0.14-0.83)
    Ptrend0.100.02
IGFBP-1 (mean, ng/mL)
    9.6 ± 3.9100311.00151.00
    27.0 ± 6.199331.27 (0.64-2.54)211.40 (0.56-3.47)
    63.6 ± 21.099350.93 (0.45-1.92)170.49 (0.18-1.35)
    Ptrend0.850.16
IGFBP-3 (mean, ng/mL)
    2381.9 ± 544.0100321.00211.00
    3622.6 ± 283.0100371.29 (0.64-2.60)181.05 (0.43-2.54)
    5198.2 ± 1047.299301.19 (0.56-2.53)141.30 (0.50-3.43)
    Ptrend0.660.63
IGF-I/IGFBP-3 (mean, ng/mL)
    0.07 ± 0.02100351.00201.00
    0.12 ± 0.0199310.70 (0.36-1.38)180.69 (0.30-1.62)
    0.19 ± 0.0599330.66 (0.34-1.29)140.43 (0.17-1.06)
    Ptrend0.230.07
  • * Models adjusted for age, calcium intake, previous polyp, number of adenomas at baseline, number of colonoscopies, and baseline IGF-I levels (except for IGF-I and IGF-I/IGFBP-3 ratio).