Table 3.

Crude and adjusted ORs (95% CIs) for baseline tertiles of plasma IGF biomarkers and colorectal adenoma recurrence

BiomarkerRecur/totalCrude OR (95% CI)Adjusted* OR (95% CI)
IGF-I (mean, ng/mL)
    68.0 ± 22.862/1001.001.00
    116.4 ± 12.251/990.65 (0.37-1.14)0.55 (0.29-1.01)
    176.3 ± 35.545/990.51 (0.29-0.90)0.49 (0.26-0.91)
    Ptrend0.020.02
IGFBP-1 (mean, ng/mL)
    9.6 ± 3.949/1001.001.00
    27.0 ± 6.157/991.41 (0.81-2.47)1.40 (0.75-2.65)
    63.6 ± 21.053/991.20 (0.69-2.09)0.82 (0.42-1.61)
    Ptrend0.520.58
IGFBP-3 (mean, ng/mL)
    2,381.9 ± 544.055/1001.001.00
    3,622.6 ± 283.056/1001.04 (0.60-1.82)1.12 (0.59-2.12)
    5,198.2 ± 1,047.248/990.77 (0.44-1.34)1.17 (0.59-2.31)
    Ptrend0.360.65
IGF-I/IGFBP-3
    0.07 ± 0.0258/1001.001.00
    0.12 ± 0.0152/990.80 (0.46-1.40)0.71 (0.38-1.30)
    0.19 ± 0.0548/990.68 (0.39-1.19)0.58 (0.31-1.08)
    Ptrend0.180.08
  • * Models adjusted for age, calcium intake, previous polyp, number of adenomas at baseline, number of colonoscopies, and baseline IGF-I levels (except for IGF-I and IGF-I/IGFBP-3 ratio).