Table 3.

HR (95% CI) for breast cancer and all-cause mortality according to total, moderate-intensity, or vigorous-intensity recreational physical activity after breast cancer diagnosis in the CWLS

Total recreational physical activity after diagnosis (MET-h/wk)
P for linear trend
<2.82.8-7.98.0-20.9≥21.0
Breast cancer deaths37262521
    Multivariable HR (95% CI)*1.00 (Reference)0.62 (0.37-1.03)0.53 (0.31-0.88)0.44 (0.25-0.76)0.01
    Multivariable HR (95% CI)1.00 (Reference)0.65 (0.39-1.08)0.59 (0.35-1.01)0.51 (0.29-0.89)0.05
    Multivariable HR (95% CI)1.00 (Reference)0.66 (0.39-1.13)0.61 (0.36-1.05)0.49 (0.27-0.89)0.05
Total deaths185878159
    Multivariable HR (95% CI)*1.00 (Reference)0.58 (0.45-0.75)0.52 (0.40-0.68)0.44 (0.32-0.59)<0.001
    Multivariable HR (95% CI)1.00 (Reference)0.58 (0.45-0.76)0.53 (0.40-0.69)0.44 (0.32-0.60)<0.001
    Multivariable HR (95% CI)
1.00 (Reference)
0.59 (0.45-0.77)
0.53 (0.40-0.71)
0.44 (0.32-0.61)
<0.001
Moderate-intensity§ recreational physical activity after diagnosis (MET-h/wk)
P for linear trend

<2.0
2.0-3.9
4.0-10.2
≥10.3
Breast cancer deaths35322022
    Multivariable HR (95% CI)*,1.00 (Reference)0.69 (0.43-1.12)0.47 (0.27-0.83)0.41 (0.24-0.73)0.01
    Multivariable HR (95% CI),1.00 (Reference)0.71 (0.44-1.16)0.49 (0.28-0.88)0.47 (0.26-0.83)0.03
    Multivariable HR (95% CI),1.00 (Reference)0.79 (0.47-1.31)0.56 (0.31-1.01)0.47 (0.26-0.86)0.03
Total deaths1611177262
    Multivariable HR (95% CI)*,1.00 (Reference)0.67 (0.53-0.85)0.63 (0.47-0.84)0.47 (0.35-0.64)<0.001
    Multivariable HR (95% CI),1.00 (Reference)0.66 (0.52-0.84)0.64 (0.48-0.85)0.46 (0.34-0.63)<0.001
    Multivariable HR (95% CI),
1.00 (Reference)
0.70 (0.54-0.90)
0.66 (0.49-0.90)
0.47 (0.34-0.65)
<0.001
Vigorous-intensity recreational physical activity after diagnosis (MET-h/wk)
P for linear trend

0.0
0.1-5.9
6.0-15.0
≥15.1
Breast cancer deaths55182412
    Multivariable HR (95% CI)*,**1.00 (Reference)0.94 (0.55-1.61)1.07 (0.65-1.76)0.90 (0.47-1.72)0.79
    Multivariable HR (95% CI),**1.00 (Reference)0.98 (0.57-1.69)1.15 (0.70-1.90)1.02 (0.53-1.97)0.92
    Multivariable HR (95% CI),**1.00 (Reference)0.94 (0.53-1.68)1.10 (0.65-1.85)1.10 (0.57-2.13)0.74
Total deaths265486039
    Multivariable HR (95% CI)*,**1.00 (Reference)0.70 (0.51-0.95)0.71 (0.53-0.95)0.82 (0.58-1.16)0.20
    Multivariable HR (95% CI),**1.00 (Reference)0.70 (0.51-0.95)0.74 (0.55-0.99)0.82 (0.58-1.16)0.21
    Multivariable HR (95% CI),**1.00 (Reference)0.72 (0.53-1.00)0.75 (0.55-1.01)0.85 (0.59-1.22)0.31
  • * Multivariable HR (95% CI) adjusted for age at diagnosis, stage of disease at diagnosis, state of residence at diagnosis, and interval between diagnosis and physical activity assessment.

  • Additionally adjusted for postdiagnosis BMI, postdiagnosis menopausal status, postdiagnosis hormone therapy use, total energy intake year before enrollment in the CWLS, education level at diagnosis, family history of breast cancer at diagnosis, and initial treatment modality (radiation, chemotherapy, tamoxifen).

  • Excludes 30 women who died within 1 year of returning the CWLS questionnaire, 7 of whom died from breast cancer.

  • § Moderate-intensity recreational physical activity include activities that expend <6.0 MET: walking outdoors and stair climbing.

  • Additionally adjusted for vigorous-intensity recreational physical activity.

  • Vigorous-intensity recreational physical activity include activities that expend ≥6.0 MET: running (≥10 min/mile); calisthenics, aerobics, aerobic dance, and rowing machine; tennis, squash, or racquetball; lap swimming; and other aerobic recreation (e.g., lawn mowing).

  • ** Additionally adjusted for moderate-intensity recreational physical activity.