Table 5.

Geometric means (95% confidence limits) for total NNAL and 1-OHP by nicotine metabolite ratio level

Nicotine metabolite ratio*
Ptrend
Bottom tertile
Middle tertile
Top tertile
nMean (95% CI)nMean (95% CI)nMean (95% CI)
Total NNAL (pmol/mL)
    All*1930.70 (0.64-0.76)1920.79 (0.72-0.85)1930.80 (0.73-0.87)0.03
    Native Hawaiian650.61 (0.53-0.71)620.72 (0.62-0.84)610.69 (0.59-0.81)0.17
    White340.95 (0.78-1.16)720.90 (0.79-1.03)910.99 (0.88-1.12)0.61
    Japanese American940.63 (0.56-0.71)580.73 (0.63-0.86)410.74 (0.62-0.89)0.16
1-OHP (pmol/mL)
    All*1920.40 (0.31-0.51)1880.34 (0.26-0.43)1900.50 (0.39-0.65)0.47
    Native Hawaiian650.37 (0.23-0.59)600.35 (0.22-0.56)600.50 (0.31-0.81)0.65
    White340.40 (0.23-0.68)710.31 (0.22-0.45)900.52 (0.37-0.71)0.58
    Japanese American930.42 (0.30-0.60)570.35 (0.22-0.54)400.52 (0.31-0.88)0.54
  • NOTE: Mean total NNAL (NNAL + NNAL-Gluc) and mean 1-OHP were adjusted for age, sex, CPD, and 12 h urine volume by multiple covariance analysis. Tertile categorization for nicotine metabolite ratio was based on all participants. First tertile: ≤0.484; second tertile: 0.484 to 1.10; and third tertile: >1.10.

  • * P values for trend were obtained by treating nicotine metabolite ratio as a continuous variable.

  • Further adjusted for race.