Table 1.

Characteristics of postmenopausal cases and controls according to breast cancer subtypes, MARIE Study, Germany, 2002-2005

CharacteristicCases*
Controls
ER+/PR+
ER+/PR−
ER−/PR+
ER−/PR−
In situ
n (%)n (%)n (%)n (%)n (%)n (%)
Total2,004 (100)495 (100)103 (100)545 (100)205 (100)6,569 (100)
First degree history of breast cancer
    No1,541 (76.9)380 (76.8)82 (79.6)424 (77.8)146 (71.2)5,422 (82.5)
    Yes346 (17.3)88 (17.8)15 (14.6)94 (17.2)49 (23.9)767 (11.7)
    Unknown117 (5.8)27 (5.5)6 (5.8)27 (5.0)10 (4.9)380 (5.8)
Age at menarche
    <12150 (7.5)51 (10.3)10 (9.7)47 (8.6)11 (5.4)528 (8.0)
    12-141,324 (66.1)312 (63.0)68 (66.0)338 (62.0)125 (61.0)4,150 (63.2)
    15-17528 (26.3)131 (26.5)25 (24.3)158 (29.0)69 (33.7)1,876 (28.6)
    Unknown2 (0.1)1 (0.2)2 (0.4)15 (0.2)
Parity (gestation ≥ 28 wk)
    0352 (17.6)91 (18.4)15 (14.6)83 (15.2)44 (21.5)1,029 (15.7)
    1575 (28.7)153 (30.9)33 (32.0)149 (27.3)53 (25.9)1,664 (25.3)
    2732 (36.5)167 (33.7)30 (29.1)214 (39.3)86 (42.0)2,522 (38.4)
    3+345 (17.2)84 (17.0)25 (24.3)99 (18.2)22 (10.7)1,354 (20.6)
Ever breastfeeding
    No760 (37.9)178 (36.0)39 (37.9)190 (34.9)82 (40.0)2,194 (33.4)
    Yes1,243 (62.0)317 (64.0)64 (62.1)355 (65.1)123 (60.0)4,375 (66.6)
    Unknown1 (0.0)
Type of menopause
    Natural1,035 (51.6)266 (53.7)49 (47.6)293 (53.8)85 (41.5)3,610 (55.0)
    Induced145 (7.2)37 (7.5)12 (11.7)30 (5.5)22 (10.7)500 (7.6)
    Hysterectomy455 (22.7)104 (21.0)23 (22.3)128 (23.5)59 (28.8)1,477 (22.5)
    Hormone therapy339 (16.9)80 (16.2)13 (12.6)83 (15.2)36 (17.6)880 (13.4)
    Other30 (1.5)8 (1.6)6 (5.8)11 (2.0)3 (1.5)102 (1.6)
Mammograms
    No mammogram232 (11.6)39 (7.9)14 (13.6)82 (15.0)7 (3.4)723 (11.0)
    1-4 mammograms637 (31.8)201 (40.6)36 (35.0)197 (36.1)43 (21.0)2,881 (43.9)
    5-9 mammograms507 (25.3)119 (24.0)21 (20.4)134 (24.6)65 (31.7)1,555 (23.7)
    10+ mammograms610 (30.4)131 (26.5)32 (31.1)126 (23.1)89 (43.4)1,356 (20.6)
    Unknown18 (0.8)5 (1.0)6 (1.1)1 (0.5)54 (0.8)
Ever benign breast disease
    No1,184 (59.1)296 (59.8)57 (55.3)316 (58.0)91 (44.4)4,323 (65.8)
    Yes818 (40.8)198 (40.0)45 (43.7)229 (42.0)112 (54.6)2,226 (33.9)
    Unknown3 (0.1)1 (0.2)1 (1.0)2 (1.0)20 (0.3)
Hormone therapy use
    Never619 (30.9)170 (34.3)35 (34.0)207 (38.0)46 (22.4)2,650 (40.3)
    Current or within last 6 mo991 (49.5)218 (44.0)48 (46.6)188 (34.5)111 (54.1)2,179 (33.2)
    Recency: 7-12 mo52 (2.6)10 (2.0)1 (1.0)17 (3.1)8 (3.9)133 (2.0)
    1-< 3 y125 (6.2)39 (7.9)3 (2.9)47 (8.6)17 (8.3)539 (8.2)
    3-< 5 y63 (3.1)18 (3.6)4 (3.9)23 (4.2)5 (2.4)262 (4.0)
    5-< 10 y78 (3.9)27 (5.5)5 (4.9)37 (6.8)10 (4.9)373 (5.7)
    10-< 15 y28 (1.4)6 (1.2)1 (1.0)13 (2.4)3 (1.5)197 (3.0)
    15+ y32 (1.6)3 (0.6)3 (2.9)12 (2.2)4 (2.0)181 (2.8)
Occupational status
    Blue collar worker258 (12.9)63 (12.7)17 (16.5)81 (14.9)17 (8.3)791 (12.0)
    Simple employee470 (23.4)124 (25.1)17 (16.5)127 (23.3)52 (25.4)1,610 (24.5)
    Medium employee771 (38.5)183 (37.0)42 (40.8)214 (39.3)86 (42.0)2,575 (39.2)
    Higher employee404 (20.1)104 (21.0)22 (21.4)106 (19.4)41 (20.0)1,299 (19.8)
    Leading position91 (4.5)17 (3.4)4 (3.9)17 (3.1)9 (4.4)270 (4.1)
    Unkonwn10 (0.5)4 (0.8)1 (1.0)0 (0.0)24 (0.4)
Education
    Low1,166 (58.2)280 (56.6)60 (58.3)320 (58.7)108 (52.7)3,843 (58.5)
    Medium549 (27.4)142 (28.7)30 (29.1)149 (27.3)58 (28.3)1,840 (28.0)
    High289 (14.4)73 (14.7)13 (12.6)76 (13.9)39 (19.0)886 (13.5)
Smoking
    Never1,053 (52.5)280 (56.6)61 (59.2)315 (57.8)117 (57.1)3,468 (52.8)
    Ex-smoker569 (28.4)119 (24.0)24 (23.3)131 (24.0)56 (27.3)1,888 (28.7)
    Current smoker382 (19.1)96 (19.4)18 (17.5)99 (18.2)32 (15.6)1,210 (18.4)
    Unknown3 (0.0)
median (Q1, Q3)median (Q1, Q3)median (Q1, Q3)median (Q1, Q3)median (Q1, Q3)median (Q1, Q3)
Age years63.6 (59.5, 67.4)63.3 (59.2, 67.8)63.0 (57.9, 66.9)62.6 (58.4, 66.8)63.3 (58.9, 66.6)63.3 (59.0, 67.2)
Body mass index [kg/m2]25.5 (23.0, 28.7)25.2 (22.6, 27.9)25.2 (23.1, 27.8)24.8 (22.4, 28.4)24.4 (22.3, 27.5)25.5 (22.9, 28.7)
Adult weight gain [kg]12 (6, 19)11 (6, 18)11.5 (6, 17)11 (5, 17)10.5 (6, 17)12 (6, 19)
Age at first pregnancy ≥ 28 weeks§24 (21, 27)24 (21, 28)24 (21, 27)24 (21, 27)24 (22, 28)24 (21, 27)
Alcohol [g/day]3.66 (0.91, 10.44)3.83 (0.90, 10.79)4.14 (0.71, 9.52)2.92 (0.56, 7.71)4.65 (1.43, 10.0)3.60 (0.89, 10.47)
  • * Information on receptor status was available only for invasive carcinomas.

  • Induced menopausal status including bilateral oophorectomy/chemotherapy/radiation.

  • Benign breast disease included 'with or without biopsy'.

  • § Parous women only.