Table 4.

Enterolactone concentrations, fiber intakes, and odds ratios (95 % CI) for breast cancer across quartiles of plasma enterolactone concentration in women from the MDC cohort, 1991 to 2004

Quartiles of ENL concentration
P for trend
1234
ENL concentration (nmol/L), median (range)*4.9 (0.3-8.4)11.6 (8.5-16.1)21.1 (16.1-26.1)36.8 (26.3-334.4)
Fiber intake (g/d), median*17.617.218.919.7<0.001
All women
    Age (y), median56.456.356.755.40.83
    Cases/controls100/183104/18378/18584/182
    OR (95 % CI)1.001.06 (0.74-1.51)0.77 (0.53-1.11)0.84 (0.58-1.20)0.16
    OR (95 % CI)1.001.03 (0.70-1.52)0.70 (0.46-1.06)0.81 (0.55-1.20)0.14
Women above 50 years + exclusion of cases with diagnosis within 1 y
    Cases/controls73/14580/13366/13457/136
    OR (95 % CI)1.001.23 (0.82-1.86)0.99 (0.65-1.50)0.84 (0.55.1.27)0.30
    OR (95 % CI)1.001.25 (0.78-2.00)0.89 (0.55-1.45)0.73 (0.45-1.19)0.13
    OR(95 % CI; 2nd quartile as reference)0.80 (0.50-1.28)1.000.71 (0.44-1.15)0.59 (0.35-0.97)0.04§
  • Abbreviation: OR, odds ratio; ENL, enterolactone.

  • * Estimated for all women (n = 1099).

  • Crude analysis.

  • Adjusted for weight, height, educational status, smoking habits, leisure-time physical activity, household activities, alcohol habits, age at menopause, parity, age at birth of first child, and current use of menopausal hormone therapy.

  • § Test of trend from quartiles 2 to 4.