Table 4.

Stratified analysis for XRCC3 T241M and TP53 R72P by ethnicity, smoking status, and histology

Gene variantNo. studiesNo. casesNo. controlsHeterozygotes OR (95% CI)Homozygotes OR (95% CI)Per allele OR (95% CI)PtrendPheterogeneity
XRCC3 T241M
Ethnicity
    Non-Hispanic Whites*53,0424,6440.89 (0.80-0.99)0.84 (0.71-1.00)0.91 (0.84-0.98)0.010.54
    Asian*34253770.82 (0.49-1.37)0.92 (0.12-6.98)0.84 (0.48-1.49)0.550.22
Smoking
    Never64771,9511.03 (0.78-1.36)1.28 (0.86-1.92)1.10 (0.91-1.33)0.320.50
    Ever*72,9853,0620.85 (0.76-0.96)0.78 (0.65-0.94)0.87 (0.80-0.95)0.0020.73
        Former*56861,4100.79 (0.63-0.98)0.77 (0.55-1.09)0.86 (0.73-1.00)0.050.93
        Current*52,2291,5870.91 (0.78-1.05)0.80 (0.54-1.20)0.90 (0.79-1.03)0.110.32
Histology
    Squamous cell*51,3503,8320.88 (0.71-1.11)0.78 (0.62-0.99)0.90 (0.74-1.08)0.240.14
    Small cell*44143,4260.84 (0.66-1.08)0.66 (0.44-0.98)0.83 (0.70-0.98)0.030.82
    Adenocarcinoma*69354,7410.88 (0.74-1.05)1.04 (0.80-1.34)0.98 (0.87-1.10)0.720.87
Gender
    Male72,5463,3480.87 (0.76-0.99)0.83 (0.69-1.01)0.90 (0.82-0.98)0.020.49
    Female78511,6640.91 (0.74-1.13)0.90 (0.64-1.26)0.94 (0.81-1.10)0.440.44
TP53 R72P
Ethnicity
    Non-Hispanic Whites*53,1594,6051.14 (0.94-1.39)1.19 (0.97-1.45)1.12 (0.99-1.26)0.070.20
    Asian*22323321.30 (0.87-1.95)1.46 (0.87-2.47)1.23 (0.95-1.59)0.920.85
Smoking
    Never64242,0821.16 (0.91-1.48)0.96 (0.64-1.43)1.03 (0.87-1.22)0.690.59
    Ever*53,1813,2031.17 (0.96-1.41)1.37 (1.05-1.77)1.18 (1.03-1.35)0.0170.11
        Former*59291,8041.23 (1.03-1.48)1.37 (1.02-1.85)1.19 (1.05-1.36)0.0070.42
        Current*42,2511,3971.11 (0.83-1.49)1.42 (0.83-2.42)1.17 (0.91-1.50)0.200.03
Histology
    Squamous cell*51,2964,4661.26 (1.04-1.52)1.52 (1.19-1.94)1.22 (1.10-1.35)<0.0010.59
    Small cell*33763,6350.81 (0.63-1.05)1.27 (0.68-2.37)0.96 (0.80-1.15)0.640.41
    Adenocarcinoma*61,0615,2941.05 (0.90-1.22)1.00 (0.77-1.29)1.02 (0.91-1.14)0.750.60
Gender
    Male52,4953,3071.09 (0.96-1.23)1.30 (1.05-1.60)1.12 (1.02-1.22)0.010.49
    Female61,1151,9871.14 (0.95-1.36)1.10 (0.83-1.46)1.08 (0.95-1.22)0.250.75
  • * OR adjusted for age, sex, tobacco cumulative exposure (pack-years), and country when applicable.

  • OR adjusted for age, sex, and country when applicable.

  • OR adjusted for age, tobacco cumulative exposure (pack-years) and country when applicable.