Table 3.

Summary estimates of the main effects of the genetic variants

Gene variant (dbSNP no.)No. studies (reference)Case no. GG/Gg/ggControl no. GG/Gg/ggHeterozygotes OR (95% CI)Homozygotes OR (95% CI)Per allele OR (95% CI)PtrendPheterogeneity
APEX1 D148E (rs3136820)6 (10-12, 31, 33, 35)1,499/2,480/1,1011,596/2,903/1,3610.89 (0.81-0.99)0.91 (0.78-1.06)0.95 (0.88-1.02)0.140.34
OGG1 S326C (rs1052133)*4 (10-13)1,648/805/1162,628/1,389/1610.95 (0.84-1.07)1.34 (1.01-1.79)1.02 (0.93-1.13)0.630.82
XRCC1 R194W (rs1799782)5 (10-12, 14, 35)2,495/363/263,947/596/280.92 (0.79-1.08)1.57 (0.76-3.26)0.98 (0.85-1.13)0.770.54
XRCC1 R280H (rs25489)4 (12, 14, 32, 35)2,568/273/163,123/351/91.01 (0.75-1.36)2.06 (0.83-5.09)1.06 (0.83-1.37)0.620.21
XRCC1 R399Q (rs25487)9 (10-12, 14, 31-35)2,768/2,871/7932,824/2,934/7920.98 (0.88-1.08)0.93 (0.75-1.14)0.97 (0.89-1.05)0.390.26
XRCC2 R188H (rs3218536)3 (10-12)2,126/281/103,324/470/181.01 (0.84-1.21)0.90 (0.35-2.28)0.99 (0.84-1.17)0.900.74
XRCC3 T241M (rs861539)8 (10-12, 14, 33-36)1,719/1,386/3622,144/2,248/6290.89 (0.79-0.99)0.84 (0.71-1.00)0.91 (0.84-0.98)0.010.50
ERCC1 T354C (rs11615)3 (10, 12, 31)1,730/2,052/6842,034/2,373/8111.04 (0.94-1.15)1.03 (0.89-1.19)1.02 (0.95-1.09)0.560.64
ERCC1 C8092A (rs3212986)3 (12, 14, 31)2,660/1,719/3092,569/1,694/2881.00 (0.91-1.11)1.06 (0.88-1.29)1.02 (0.94-1.09)0.660.61
XPD D312N (rs1799793)9 (10, 12, 14, 24, 30-33, 35)2,875/2,988/1,0092,948/3,124/1,0110.96 (0.86-1.06)1.09 (0.97-1.23)1.03 (0.97-1.08)0.370.83
XPD K751Q (rs13181)9 (10-12, 24, 31, 33-36)2,592/2,869/1,0022,650/2,995/9580.99 (0.89-1.10)1.19 (1.02-1.39)1.07 (0.98-1.18)0.150.05
XPF R415Q (rs1800067)3 (11, 12, 14)2,201/306/132,208/390/211.00 (0.84-1.19)0.72 (0.24-2.13)0.96 (0.82-1.13)0.650.66
XPG H1104D (rs17655)5 (11, 12, 29, 24, 35)1,852/1,155/2092,485/1,510/2861.07 (0.91-1.25)1.00 (0.81-1.25)1.03 (0.93-1.13)0.620.32
XPA G23A (rs1800975)3 (12, 14, 33)1,181/1,260/3621,422/1,603/4270.85 (0.66-1.10)1.06 (0.82-1.37)0.97 (0.82-1.15)0.700.08
MGMT L84F (rs12917)3 (10, 14, 35)366/143/191,121/391/330.92 (0.60-1.41)1.53 (0.76-3.08)1.02 (0.73-1.42)0.910.13
MGMT I143V (rs2308321)3 (11, 12, 14)1,696/538/452,594/675/511.06 (0.94-1.20)1.05 (0.91-1.20)1.19 (0.71-1.99)0.500.31
MGMT K178R (rs2308327)3 (12, 14, 35)1,800/528/1082,342/621/1121.08 (0.93-1.26)1.27 (0.63-2.54)1.07 (0.91-1.25)0.410.31
TP53 R72P (rs1042522)6 (10, 12, 13, 30, 33, 36)1,764/1,480/3662,733/2,079/4811.14 (1.00-1.29)1.20 (1.02-1.42)1.10 (1.02-1.18)0.010.40
  • NOTE: OR, individual OR adjusted for age, sex, cumulative tobacco smoking (as pack-years), and country when applicable. GG/Gg/gg, major allele homozygotes/heterozygotes/minor allele homozygotes.

  • * Estimates in non-Hispanic Whites only due to the significant heterogeneity by ethnicity and limited data on Asians.

  • Norway study was excluded as it conferred an outlying estimate and contributed to the majority of the heterogeneity.