Table 2.

Characteristics of Nurses' Health Study sample eligible for inclusion in the TMA

CharacteristicEligible cases in the NHSCases in the NHS with a tumor block or slideCases included in the final TMA analysis
N (%)672 (100%)346 (51%)174 (26%)
Age at diagnosis, mean (SD)59.4 (9.3)61.7 (9.2)61.2 (8.9)
Lapse between date of diagnosis and date of tissue collection, years, mean (SD)12.6 (6.8)10.2 (5.9)10.0 (6.0)
Lapse between date of diagnosis and date of tissue collection, n (%)*
    0 to 5 y112 (17%)80 (23%)43 (25%)
    >5 to 10 y160 (24%)124 (36%)61 (35%)
    ≥10 to 27 y385 (59%)142 (41%)70 (40%)
Parity, mean (SD)3.8 (1.7)3.8 (1.7)3.8 (1.7)
Oral contraceptive use, ever, n (%)248 (37%)137 (40%)71 (41%)
Tubal ligation, ever, n (%)70 (10%)45 (13%)22 (13%)
Body mass index in 1990, mean (SD)25.6 (5.3)25.4 (5.0)25.1 (5.0)
Histology, N (%)
    Serous430 (64%)215 (62%)102 (59%)
    Endometrioid97 (14%)55 (16%)30 (17%)
    Mucinous64 (10%)29 (8%)15 (9%)
    Clear cell32 (5%)16 (5%)12 (7%)
    Other§49 (7%)31 (9%)15 (9%)
Morphology, n (%)
    Borderline72(11%)35 (10%)21 (12%)
    Invasive598 (89%)309 (89%)153 (88%)
    Unknown2 (<0.3%)2 (1%)0
Disease stage, n (%)
    I, II231 (34%)120 (35%)74 (43%)
    III, IV426 (64%)220 (63%)100 (57%)
    Other/unknown15 (2%)6 (2%)0
  • Abbreviation: NHS, Nurses' Health Study.

  • * The total is not 672 due to missing information (tissue collection date).

  • Among parous women.

  • Histologic classification based on pathology report. Samples included in the TMA were verified by microscope review.

  • § Other includes transitional, carcinosarcoma, mixed histology, or unknown.