Table 4.

Odds ratios of colorectal cancer (95% confidence intervals) by increase in HbA1c in women, by cancer site

	Quintiles									OR per 10% increase in HbA1c
		1	2	3	4	5				OR per 10% increase in HbA1c
Colorectum	≤5.4	]5.4-5.6]	]5.6-5.8]	]5.8-6.1]	>6.1
No. cases/controls	96/91	84/109	85/114	118/97	82/54
Crude*	1.00	0.72 (0.47-1.09)	0.71 (0.46-1.09)	1.14 (0.75-1.73)	1.46 (0.91-2.33)	1.19 (1.04-1.35)
Adjusted^†	1.00	0.74 (0.48-1.13)	0.71 (0.46-1.10)	1.13 (0.74-1.71)	1.40 (0.87-2.24)	1.16 (1.01-1.32)
Nondiabetics	≤5.4	]5.4-5.6]	]5.6-5.7]	]5.7-5.9]	>5.9
No. cases/controls	90/80	79/99	39/53	77/87	105/71
Adjusted^†	1.00	0.72 (0.46-1.13)	0.69 (0.41-1.16)	0.78 (0.49-1.23)	1.32 (0.83-2.10)	1.28 (0.99-1.67)
Colon	≤5.4	]5.4-5.6]	]5.6-5.8]	]5.8-6.1]	>6.1
No. cases/controls	62/55	51/66	56/80	82/67	51/34
Crude*	1.00	0.67 (0.39-1.13)	0.62 (0.37-1.04)	1.09 (0.66-1.79)	1.34 (0.75-2.38)	1.15 (0.97-1.37)
Adjusted^†	1.00	0.69 (0.40-1.18)	(0.63 0.37-1.05)	1.09 (0.66-1.82)	1.30 (0.72-2.33)	1.12 (0.93-1.34)
Nondiabetics	≤5.4	]5.4-5.6]	]5.6-5.7]	]5.7-5.9]	>5.9
No. cases/controls	57/50	48/60	22/38	54/60	79/52
Adjusted^†	1.00	0.73 (0.42-1.27)	0.55 (0.28-1.06)	0.79 (0.46-1.37)	1.38 (0.80-2.38)	1.32 (0.96-1.80)
Rectum	≤5.4	]5.4-5.6]	]5.6-5.8]	]5.8-6.1]	>6.1
No. cases/controls	34/36	33/43	29/34	36/30	31/20
Crude*	1.00	0.84 (0.41-1.72)	0.95 (0.44-2.06)	1.29 (0.61-2.74)	1.75 (0.78-3.92)	1.24 (1.01-1.52)
Adjusted^†	1.00	0.86 (0.41-1.78)	0.95 (0.44-2.07)	1.28 (0.60-2.73)	1.67 (0.74-3.78)	1.22 (0.99-1.50)
Nondiabetics	≤5.4	]5.4-5.6]	]5.6-5.7]	]5.7-5.9]	>5.9
No. cases/controls	33/30	31/39	17/15	23/27	26/19
Adjusted^†	1.00	0.71 (0.32-1.55)	0.99 (0.40-2.46)	0.72 (0.30-1.72)	1.15 (0.47-2.79)	1.21 (0.74-1.97)

↵* Analysis matched on EPIC recruitment center, gender, age at blood donation, time of the day at blood donation, follow-up time, fasting status and, in women, menopausal status and phase of the menstrual cycle for premenopausal women.
↵† Adjustment for WHR and alcohol.