Table 4.

The association between CpG island hypermethylation of cancer-related genes and selected factors analyzed by unconditional logistic regression

VariablesOR (95% CI)*
Cancer tissue
Remote normal-appearing tissue
P16MGMThMLH1Any geneP16MGMThMLH1Any gene
Age (y)1.01 (0.93-1.10)1.01 (0.95-1.08)1.01 (0.92-1.11)0.96 (0.91-1.02)0.91 (0.83-1.00)0.94 (0.89-1.00)
Sex
    Men1.001.001.001.001.001.00
    Women1.26 (0.36-4.38)1.32 (0.53-3.24)0.85 (0.22-3.19)1.57 (0.70-3.50)2.37 (0.65-8.65)2.30 (1.03-5.13)
Folate intake
    Q11.001.001.001.001.001.00
    Q21.56 (0.37-6.53)2.53 (0.89-7.14)2.59 (0.43-15.50)0.99 (0.38-2.56)2.65 (0.58-11.99)1.11 (0.44-2.81)
    Q30.74 (0.19-2.87)0.58 (0.15-2.21)0.56 (0.14-2.34)1.35 (0.48-3.83)0.34 (0.03-3.87)1.23 (0.44-3.48)
    Q45.09 (1.02-25.36)1.09 (0.22-5.30)4.23 (0.51-34.79)1.35 (0.29-6.21)
MTHFR C677T
    CC1.001.001.001.001.001.00
    CT0.54 (0.12-2.31)3.34 (1.07-10.39)0.80 (0.17-3.78)0.66 (0.26-1.68)2.90 (0.63-13.33)0.81 (0.33-2.00)
    TT0.89 (0.16-4.88)3.83 (1.13-12.94)1.41 (0.21-9.55)1.04 (0.38-2.85)0.80 (0.11-5.72)0.95 (0.35-2.63)
  • * Adjusted by age, sex, folate intake, and MTHFR C677T genotypes.

  • The cut point of fruit folate intake is quartile (μg/d): Q1, 0; Q2, 26.3; Q3, 99.5; and Q4, 311.1.