Table 3.

Association between clinical characteristics and hypermethylation in the ESCC

VariablesnFrequency of hypermethylation (%)
Cancer tissue
Remote normal-appearing tissue
P16MGMThMLH1Any geneP16MGMThMLH1Any gene
Site
    Upper2319 (82.6)8 (34.8)1 (4.3)21 (91.3)8 (34.8)3 (13.0)010 (43.5)
    Middle6861 (89.7)14 (20.6)2 (2.9)61 (89.7)27 (39.7)7 (10.3)029 (42.6)
    Low3430 (88.2)12 (35.3)1 (2.9)31 (91.2)11 (32.4)4 (11.8)015 (44.1)
P0.653*0.1931.000*1.000*0.7500.929*0.990
TNM stage
T
    T1/T26764 (95.5)18 (26.9)2 (3.0)64 (95.5)23 (34.3)8 (11.9)027 (40.3)
    T3/T45846 (79.3)16 (27.6)2 (3.5)49 (84.5)23 (39.7)6 (10.3)027 (46.6)
P0.0050.9281.000*0.0370.5380.7780.482
N
    N06660 (90.9)12 (18.2)2 (3.0)60 (90.9)17 (25.8)7 (10.6)021 (31.8)
    N15950 (84.7)22 (37.3)2 (3.4)53 (89.8)29 (49.2)7 (11.9)033 (55.9)
P0.2900.0171.000*0.8380.0070.8240.007
M
    M0124109 (87.9)33 (26.6)4 (3.2)112 (90.3)45 (36.3)14 (11.3)053 (42.7)
    M111 (100)1 (100)01 (100)1 (100)001 (100)
P1.000*0.272*1.000*1.000*0.368*1.000*0.432*
  • Abbreviation: TNM, tumor-node-metastasis.

  • * Fisher's exact test.