Table 4.

Univariate analysis to identify factors predicting TSG methylation or marked atypia

FactorMethylation of ≥2 genes
Marked atypia
Pos/Neg (%)OR (95% CI)PPos/Neg (%)OR (95% CI)P
Age (tertiles)
    ≤41.39/93 (10)19/114 (8)1
    41.4-50.112/97 (12)1.32 (0.53-3.29)0.55510/114 (9)1.12 (0.44-2.87)0.811
    >50.113/88 (15)1.62 (0.65-4.00)0.29815/118 (13)1.70 (0.71-4.06)0.232
Race
    Non-Caucasian6/42 (14)110/50 (20)1
    Caucasian28/236 (12)0.81 (0.31-2.09)0.66024/296 (24)0.35 (0.16-0.79)0.012
Menopausal status
    Premenopausal18/152 (12)115/183 (8)1
    Perimenopausal6/18 (33)3.72 (1.24-11.15)0.0195/19 (26)3.98 (1.26-12.55)0.019
    Postmenopausal10/108 (9)0.76 (0.34-1.72)0.50914/145 (10)1.19 (0.56-2.55)0.655
NAF production
    NAF(−)11/87 (13)110/123 (8)1
    NAF(+)23/191 (12)0.95 (0.44-2.05)0.90024/223 (11)1.37 (0.63-2.97)0.425
Cellularity
    <100 cells5/79 (6)15/119 (4)1
    100-999 cells12/133 (9)1.47 (0.50-4.33)0.48716/157 (10)2.59 (0.92-7.27)0.072
    ≥1,000 cells17/66 (26)5.14 (1.78-14.83)0.00313/70 (19)5.20 (1.77-15.29)0.003
Risk classification
    Gail lower10/126 (8)17/155 (5)1
    Gail high9/54 (17)2.32 (0.89-6.08)0.0876/61 (10)2.31 (0.74-7.16)0.149
    Contralateral8/47 (17)2.38 (0.88-6.46)0.0899/59 (15)3.81 (1.35-10.75)0.012
    Ipsilateral7/51 (14)1.85 (0.66-5.15)0.24212/71 (17)4.30 (1.61-11.45)0.004
Mild atypia
    None26/222 (12)1
    Mild atypia8/56 (14)1.26 (0.54-2.95)0.600
Marked atypia
    None26/247 (11)1
    Marked atypia8/31 (26)2.96 (1.20-7.28)0.018
Any atypia
    None19/204 (9)1
    Any atypia15/74 (20)2.48 (1.18-5.18)0.016
Masood score
    <1522/232 (9)1
    ≥1512/46 (26)3.37 (1.53-7.43)0.003