Table 2.

Crude and adjusted associations between serum 25(OH)D concentration and risk of squamous dysplasia in the Cytology Sampling Study 2 cohort

25(OH)D Quartiles*
Ptrend
Q1 (ref)Q2, RR (95% CI)Q3, RR (95% CI)Q4, RR (95% CI)
Overall
    Crude1.01.37 (0.96-1.99)1.42 (1.00-2.06)1.82 (1.32-2.57)0.0003
    Multivariate1.01.43 (1.00-2.06)1.47 (1.04-2.12)1.86 (1.35-2.62)0.0002
Men
    Crude1.01.38 (0.84-2.36)1.41 (0.86-2.41)1.57 (0.98-2.64)0.0848
    Multivariate§1.01.52 (0.92-2.59)1.51 (0.92-2.58)1.74 (1.08-2.93)0.0373
Women
    Crude1.01.36 (0.82-2.30)1.43 (0.87-2.41)2.04 (1.33-3.31)0.0010
    Multivariate§1.01.37 (0.84-2.32)1.45 (0.89-2.43)1.96 (1.28-3.18)0.0021
  • * 25(OH)D quartiles defined for men and women separately using the distribution in the subjects without dysplasia.

  • P for trend comes from a model in which quartiles were entered as ordinal variables.

  • Adjusted for age, height, and weight as continuous variables, sex, and tooth loss category.

  • § Adjusted for age, height, and weight as continuous variables, and tooth loss category.