Table 6.

Age-adjusted ORs for variants of selected apoptosis/cell cycle–related SNPs in the NCI adult brain tumor study, Non-Hispanic Whites only, by gender

GenotypeMales
Females
nOR (95% CI)nOR (95% CI)
Glioma
    CCND1 (rs603965)GG541.0 (reference)391.0 (reference)
AG981.3 (0.8-2.0)811.4 (0.8-2.2)
AA371.6 (0.9-2.9)321.0 (0.6-1.9)
    CCNH (rs2266690)TT1251.0 (reference)861.0 (reference)
CT530.8 (0.5-1.3)591.6 (1.0-2.4)
CC122.0 (0.7-5.3)92.5 (0.9-7.2)
    MDM2 (rs769412)AA1741.0 (reference)1391.0 (reference)
AG140.5 (0.2-0.9)160.8 (0.4-1.6)
GG10
Meningioma
    CASP8 (rs13113)TT101.0 (reference)351.0 (reference)
AT140.9 (0.4-2.1)520.8 (0.4-1.3)
AA40.6 (0.2-2.1)130.5 (0.2-1.1)
    CASP8 (rs1045485)GG221.0 (reference)691.0 (reference)
GC40.5 (0.2-1.6)311.9 (1.1-3.3)
CC25.6 (0.8-38.9)32.2 (0.4-11.4)
Acoustic neuroma
    CASP8 (rs1045485)GG181.0 (reference)261.0 (reference)
GC50.8 (0.3-2.2)142.1 (1.0-4.4)
CC038.0 (1.4-46.9)
    CCNH (rs2266690)TT101.0 (reference)221.0 (reference)
CT112.1 (0.8-5.2)161.6 (0.8-3.3)
CC24.8 (0.8-30.5)21.8 (0.3-9.4)