Adjusted ORs for variants of selected apoptosis/cell cycle–related SNPs in the NCI adult brain tumor study, Non-Hispanic Whites only
Gene polymorphism | Chromosomal location | Genotype | Glioma | Meningioma | Acoustic neuroma | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
n | OR (95% CI) | n | OR (95% CI) | n | OR (95% CI) | ||||||
CASP8 (rs13113) | 2q33-q34 | TT | 112 | 1.0 (reference) | 45 | 1.0 (reference) | 19 | 1.0 (reference) | |||
AT | 153 | 0.8 (0.6-1.1) | 66 | 0.8 (0.5-1.2) | 28 | 0.8 (0.4-1.6) | |||||
AA | 71 | 0.9 (0.6-1.4) | 17 | 0.5 (0.3-1.0) | 15 | 1.1 (0.5-2.3) | |||||
Ptrend = 0.4 | Ptrend = 0.04* | Ptrend = 0.9 | |||||||||
CASP8 (rs1045485) | 2q33-q34 | GG | 257 | 1.0 (reference) | 91 | 1.0 (reference) | 44 | 1.0 (reference) | |||
GC | 89 | 1.1 (0.8-1.6) | 35 | 1.4 (0.9-2.3) | 19 | 1.5 (0.8-2.7) | |||||
CC | 3 | 0.7 (0.2-2.8) | 3 | 4.0 (1.1-14.8)* | 3 | 5.4 (1.2-26.3)* | |||||
Ptrend = 0.6 | Ptrend = 0.03* | Ptrend = 0.03* | |||||||||
CCND1 (rs603965) | 11q13 | GG | 93 | 1.0 (reference) | 36 | 1.0 (reference) | 22 | 1.0 (reference) | |||
AG | 179 | 1.3 (1.0-1.9)* | 54 | 1.0 (0.6-1.7) | 34 | 1.2 (0.6-2.1) | |||||
AA | 69 | 1.2 (0.8-1.9) | 35 | 1.4 (0.8-2.5) | 8 | 0.6 (0.3-1.5) | |||||
Ptrend = 0.2 | Ptrend = 0.3 | Ptrend = 0.4 | |||||||||
CCNH (rs2266690) | 5q13.3-q14 | TT | 211 | 1.0 (reference) | 75 | 1.0 (reference) | 32 | 1.0 (reference) | |||
CT | 112 | 1.1 (0.8-1.5) | 46 | 1.4 (0.9-2.2) | 27 | 2.2 (1.2-3.9)* | |||||
CC | 21 | 2.3 (1.1-4.7)* | 5 | 1.4 (0.5-4.4) | 4 | 3.2 (0.9-11.9) | |||||
Ptrend = 0.07 | Ptrend = 0.1 | Ptrend = 0.004* | |||||||||
MDM2 (rs769412) | 12q14.3-q15 | AA | 313 | 1.0 (reference) | 106 | 1.0 (reference) | 57 | 1.0 (reference) | |||
AG | 30 | 0.6 (0.4-1.0) | 20 | 1.3 (0.7-2.3) | 8 | 1.0 (0.5-2.4) | |||||
GG | 1 | 0.8 (0.1-9.6) | 0 | — | 0 | — | |||||
Ptrend = 0.06 | Ptrend = 0.5 | Ptrend = 0.9 |
↵* Models adjusted for study matching factors age, sex, study site, and residential proximity to treatment hospital.