Table 5.

Adjusted ORs for variants of selected apoptosis/cell cycle–related SNPs in the NCI adult brain tumor study, Non-Hispanic Whites only

Gene polymorphismChromosomal locationGenotypeGlioma
Meningioma
Acoustic neuroma
nOR (95% CI)nOR (95% CI)nOR (95% CI)
CASP8 (rs13113)2q33-q34TT1121.0 (reference)451.0 (reference)191.0 (reference)
AT1530.8 (0.6-1.1)660.8 (0.5-1.2)280.8 (0.4-1.6)
AA710.9 (0.6-1.4)170.5 (0.3-1.0)151.1 (0.5-2.3)
Ptrend = 0.4Ptrend = 0.04*Ptrend = 0.9
CASP8 (rs1045485)2q33-q34GG2571.0 (reference)911.0 (reference)441.0 (reference)
GC891.1 (0.8-1.6)351.4 (0.9-2.3)191.5 (0.8-2.7)
CC30.7 (0.2-2.8)34.0 (1.1-14.8)*35.4 (1.2-26.3)*
Ptrend = 0.6Ptrend = 0.03*Ptrend = 0.03*
CCND1 (rs603965)11q13GG931.0 (reference)361.0 (reference)221.0 (reference)
AG1791.3 (1.0-1.9)*541.0 (0.6-1.7)341.2 (0.6-2.1)
AA691.2 (0.8-1.9)351.4 (0.8-2.5)80.6 (0.3-1.5)
Ptrend = 0.2Ptrend = 0.3Ptrend = 0.4
CCNH (rs2266690)5q13.3-q14TT2111.0 (reference)751.0 (reference)321.0 (reference)
CT1121.1 (0.8-1.5)461.4 (0.9-2.2)272.2 (1.2-3.9)*
CC212.3 (1.1-4.7)*51.4 (0.5-4.4)43.2 (0.9-11.9)
Ptrend = 0.07Ptrend = 0.1Ptrend = 0.004*
MDM2 (rs769412)
12q14.3-q15AA3131.0 (reference)1061.0 (reference)571.0 (reference)
AG300.6 (0.4-1.0)201.3 (0.7-2.3)81.0 (0.5-2.4)
GG10.8 (0.1-9.6)00
Ptrend = 0.06Ptrend = 0.5Ptrend = 0.9
  • * Models adjusted for study matching factors age, sex, study site, and residential proximity to treatment hospital.