Table 5.

Adjusted ORs for variants of selected apoptosis/cell cycle–related SNPs in the NCI adult brain tumor study, Non-Hispanic Whites only

Gene polymorphism	Chromosomal location	Genotype	Glioma			Meningioma			Acoustic neuroma
Gene polymorphism	Chromosomal location	Genotype				n	OR (95% CI)	n	OR (95% CI)	n	OR (95% CI)
CASP8 (rs13113)	2q33-q34	TT	112	1.0 (reference)	45	1.0 (reference)	19	1.0 (reference)
				AT	153	0.8 (0.6-1.1)	66	0.8 (0.5-1.2)	28	0.8 (0.4-1.6)
				AA	71	0.9 (0.6-1.4)	17	0.5 (0.3-1.0)	15	1.1 (0.5-2.3)
						P_trend = 0.4		P_trend = 0.04*		P_trend = 0.9
CASP8 (rs1045485)	2q33-q34	GG	257	1.0 (reference)	91	1.0 (reference)	44	1.0 (reference)
				GC	89	1.1 (0.8-1.6)	35	1.4 (0.9-2.3)	19	1.5 (0.8-2.7)
				CC	3	0.7 (0.2-2.8)	3	4.0 (1.1-14.8)*	3	5.4 (1.2-26.3)*
						P_trend = 0.6		P_trend = 0.03*		P_trend = 0.03*
CCND1 (rs603965)	11q13	GG	93	1.0 (reference)	36	1.0 (reference)	22	1.0 (reference)
				AG	179	1.3 (1.0-1.9)*	54	1.0 (0.6-1.7)	34	1.2 (0.6-2.1)
				AA	69	1.2 (0.8-1.9)	35	1.4 (0.8-2.5)	8	0.6 (0.3-1.5)
						P_trend = 0.2		P_trend = 0.3		P_trend = 0.4
CCNH (rs2266690)	5q13.3-q14	TT	211	1.0 (reference)	75	1.0 (reference)	32	1.0 (reference)
				CT	112	1.1 (0.8-1.5)	46	1.4 (0.9-2.2)	27	2.2 (1.2-3.9)*
				CC	21	2.3 (1.1-4.7)*	5	1.4 (0.5-4.4)	4	3.2 (0.9-11.9)
						P_trend = 0.07		P_trend = 0.1		P_trend = 0.004*
MDM2 (rs769412)	12q14.3-q15	AA	313	1.0 (reference)	106	1.0 (reference)	57	1.0 (reference)
				AG	30	0.6 (0.4-1.0)	20	1.3 (0.7-2.3)	8	1.0 (0.5-2.4)
				GG	1	0.8 (0.1-9.6)	0	—	0	—
						P_trend = 0.06		P_trend = 0.5		P_trend = 0.9

↵* Models adjusted for study matching factors age, sex, study site, and residential proximity to treatment hospital.