Table 3.

ORs for variants of apoptosis/cell cycle–related SNPs in the NCI adult brain tumor study, 1994 to 1998 (models adjusted for study matching factors age, sex, race/ethnicity, study site, and residential proximity to treatment hospital)

Gene polymorphismChromosomal locationGenotypeControls (n = 553)
Glioma (n = 388)
Meningioma (n = 162)
Acoustic neuroma (n = 73)
nnOR (95% CI)nOR (95% CI)nOR (95% CI)
CASP8 (rs13113)2q33-q34TT1551291.0 (reference)601.0 (reference)221.0 (reference)
AT2581660.8 (0.6-1.1)780.8 (0.5-1.2)300.8 (0.5-1.6)
AA98750.9 (0.6-1.3)180.5 (0.3-0.9)*171.1 (0.6-2.3)
Ptrend = 0.4Ptrend = 0.03*Ptrend = 0.8
AT or AA0.8 (0.6-1.1)0.7 (0.5-1.1)0.9 (0.5-1.6)
CASP8 (rs1045485)2q33-q34GG4262841.0 (reference)1171.0 (reference)501.0 (reference)
GC118951.2 (0.8-1.6)381.4 (0.9-2.1)201.5 (0.8-2.6)
CC630.7 (0.1-2.8)53.6 (1.0-13.1)*35.6 (1.2-26.6)*
Ptrend = 0.6Ptrend = 0.04*Ptrend = 0.04*
GC or CC1.1 (0.8-1.5)1.5 (1.0-2.3)*1.6 (0.9-2.8)
CCND1 (rs678653)11q13GG1981381.0 (reference)721.0 (reference)241.0 (reference)
GC2431881.1 (0.8-1.5)550.6 (0.4-1.0)331.2 (0.7-2.1)
CC74460.9 (0.6-1.4)260.9 (0.5-1.6)131.5 (0.7-3.3)
Ptrend = 1.0Ptrend = 0.3Ptrend = 0.3
GC or CC1.1 (0.8-1.4)0.7 (0.5-1.0)1.2 (0.7-2.2)
CCND1 (rs603965)11q13GG1831051.0 (reference)471.0 (reference)251.0 (reference)
AG2451961.4 (1.0-1.9)*631.1 (0.7-1.7)361.2 (0.7-2.1)
AA100731.3 (0.8-1.9)411.5 (0.9-2.5)100.7 (0.3-1.6)
Ptrend = 0.2Ptrend = 0.2Ptrend = 0.6
AG or AA1.3 (1.0-1.8)*1.2 (0.8-1.8)1.0 (0.6-1.8)
CCNH (rs2266690)5q13.3-q14TT3452381.0 (reference)971.0 (reference)381.0 (reference)
CT1661171.0 (0.7-1.3)521.2 (0.8-1.8)281.8 (1.0-3.1)*
CC16212.0 (1.0-3.9)*51.1 (0.4-3.2)42.2 (0.6-7.8)
Ptrend = 0.2Ptrend = 0.5Ptrend = 0.02*
CT or CC1.1 (0.8-1.4)1.2 (0.8-1.8)1.8 (1.1-3.2)*
CDKN1A (rs1801270)6p21.2CC4343161.0 (reference)1251.0 (reference)551.0 (reference)
AC90500.8 (0.6-1.2)240.8 (0.5-1.4)121.1 (0.5-2.2)
AA582.4 (0.7-7.8)20.5 (0.1-3.3)24.8 (0.5-43.4)
Ptrend = 0.9Ptrend = 0.4Ptrend = 0.4
AC or AA0.9 (0.6-1.3)0.8 (0.5-1.4)1.2 (0.6-2.3)
CDKN2A (rs3731249)9p21GG5233591.0 (reference)1541.0 (reference)691.0 (reference)
AG24241.4 (0.8-2.5)50.7 (0.2-1.9)41.1 (0.3-3.4)
AA
Ptrend = 0.3Ptrend = 0.5Ptrend = 0.9
AG or AA1.4 (0.8-2.5)
CHEK1 (rs506504)11q24-q24GG4743361.0 (reference)1431.0 (reference)661.0 (reference)
AG42341.1 (0.7-1.8)90.8 (0.4-1.7)61.1 (0.4-2.7)
AA134.8 (0.5-47.4)00
Ptrend = 0.3Ptrend = 0.5Ptrend = 0.9
AG or AA1.2 (0.8-1.9)
CHEK2 (rs2267130)22q12.1AA1671061.0 (reference)481.0 (reference)211.0 (reference)
AG2402021.3 (0.9-1.8)761.4 (0.9-2.2)311.0 (0.5-1.8)
GG104630.9 (0.6-1.4)321.2 (0.7-2.2)151.1 (0.5-2.2)
Ptrend = 1.0Ptrend = 0.4Ptrend = 0.9
AG or GG1.2 (0.9-1.6)1.3 (0.9-2.1)1.0 (0.6-1.8)
MDM2 (rs769412)12q14.3-q15AA4633451.0 (reference)1261.0 (reference)641.0 (reference)
AG70320.6 (0.4-0.9)*281.4 (0.8-2.3)80.9 (0.4-2.0)
GG210.9 (0.1-10.3)00
Ptrend = 0.03*Ptrend = 0.3Ptrend = 0.7
AG or GG0.6 (0.4-0.9)*0.9 (0.4-2.0)
PTEN (rs701848)10q23.3TT1901381.0 (reference)711.0 (reference)201.0 (reference)
CT2621840.9 (0.7-1.3)630.8 (0.5-1.1)391.4 (0.8-2.5)
CC93570.9 (0.6-1.3)230.7 (0.4-1.3)141.5 (0.7-3.2)
Ptrend = 0.5Ptrend = 0.2Ptrend = 0.2
CT or CC0.9 (0.7-1.2)0.8 (0.5-1.1)1.4 (0.8-2.5)
TP53 (rs1042522)
17p13.1
GG3002131.0 (reference)821.0 (reference)441.0 (reference)
CG2091461.0 (0.7-1.3)641.1 (0.8-1.7)240.7 (0.4-1.3)
CC38271.0 (0.6-1.7)131.1 (0.5-2.3)51.0 (0.3-2.8)
Ptrend = 0.9Ptrend = 0.6Ptrend = 0.4
CG or CC1.0 (0.8-1.3)1.1 (0.8-1.7)0.8 (0.4-1.3)
  • * Significant at P < 0.05 level.