Table 3.

MTHFR genotype and colorectal cancer risk in MMR gene mutation carriers

MTHFRHR (95% CI) univariatePHR (95% CI) adjusted*P
PolymorphismGenotype
C677 TCC1.0 (Referent)1.0 (Referent)
CT0.61 (0.40-0.94)0.0240.59 (0.38-0.91)0.018
TT0.42 (0.21-0.87)0.0190.44 (0.22-0.88)0.021
(Any variant, T) CT+TT0.57 (0.37-0.87)0.0090.55 (0.36-0.85)0.007
A1298CAA1.0 (Referent)1.0 (Referent)
AC1.27 (0.88-1.83)0.201.26 (0.87-1.82)0.22
CC1.44 (0.76-2.70)0.261.41 (0.78-2.56)0.25
(Any variant, C) AC+CC1.30 (0.92-1.85)0.141.29 (0.92-1.81)0.14
Haplotypes
n = 146677C-1298A1.0 (Referent)1.0 (Referent)
103677C-1298C0.97 (0.72-1.31)0.860.97 (0.72-1.30)0.84
140677T-1298A0.64 (0.46-0.89)0.0080.65 (0.47-0.90)0.009
1677T-1298C2.31 (1.66-3.20)0.0002.1 (1.43-3.0)0.000
  • NOTE: HRs are corrected for any familial correlation in ages of onset by applying robust variance correction.

  • * Adjusted for gender, MMR gene mutated, and MMR mutation type.

  • Genotypes are listed in the following order: homozygous WT, heterozygous, and homozygous polymorphic.