Table 4.

BMI, weight gain, and height in relation to risk of colorectal cancer, stratified by sex and family history of CRC status

MeasureCases
Controls
Case-control
Case-only
High/Int familial risk
Sporadic risk
n (%)High/Int risk
Sporadic risk
High/Int vs sporadic
n (%)ORadj (95% CI)*ORadj (95% CI)*
Women
    BMI 2 y ago (kg/m2)
        18.5-24.99208 (44.6)283 (42.6)545 (45.3)111
        25-29.99152 (32.6)225 (33.8)384 (31.9)1.03 (0.80-1.33)0.99 (0.79-1.25)1.05 (0.78-1.41)
        30+82 (17.6)112 (16.8)224 (18.6)0.85 (0.62-1.16)0.93 (0.70-1.24)1.04 (0.72-1.51)
    BMI (kg/m2) at age 20 y
        18.5-24.99330 (70.8)483 (72.6)875 (72.7)111
        25-29.9936 (7.7)43 (6.5)92 (7.7)0.90 (0.59-1.37)0.99 (0.66-1.49)1.05 (0.63-1.76)
        30+10 (2.2)13 (2.0)27 (2.2)0.81 (0.38-1.72)1.04 (0.50-2.15)1.06 (0.43-2.63)
    Weight gain since age 20 y
        Weight loss35 (7.5)50 (7.5)85 (7.1)1.23 (0.76-1.98)1.09 (0.70-1.68)0.96 (0.53-1.73)
        1-5 kg80 (17.2)117 (17.6)243 (20.2)111
        6-10 kg88 (18.9)103 (15.5)210 (17.5)1.31 (0.91-1.88)1.08 (0.77-1.53)1.19 (0.76-1.87)
        11-20 kg123 (26.4)195 (29.3)349 (29.0)1.11 (0.79-1.55)1.03 (0.76-1.39)1.08 (0.72-1.61)
        21+ kg107 (23.0)144 (21.7)258 (21.5)1.21 (0.85-1.73)1.05 (0.76-1.44)1.07 (0.70-1.64)
    Height (m)
        <1.5560 (12.9)99 (14.9)220 (18.3)111
        1.65 > height ≥ 1.55204 (43.8)296 (44.5)528 (43.9)1.43 (1.02-1.99)1.35 (1.01-1.79)1.03 (0.69-1.52)
        175 > height ≥ 1.65168 (36.1)235 (35.3)409 (34.0)1.59 (1.12-2.24)1.47 (1.09-1.99)1.00 (0.66-1.49)
        ≥1.7531 (6.7)31 (4.7)42 (3.5)2.81 (1.61-4.90)1.90 (1.09-3.30)1.36 (0.71-2.60)
Men
    BMI 2 y ago (kg/m2)
        18.5-24.99104 (22.6)127 (23.7)441 (30.1)111
        25-29.99215 (46.6)267 (49.9)738 (50.4)1.25 (0.96-1.64)1.25 (0.97-1.61)1.08 (0.76-1.52)
        30+117 (25.4)127 (23.7)264 (18.0)1.83 (1.33-2.51)1.74 (1.28-2.36)1.18 (0.79-1.74)
    BMI at age 20 y (kg/m2)
        18.5-24.99280 (60.7)334 (62.4)1,022 (69.8)111
        25-29.99106 (23.0)111 (20.8)273 (18.6)1.37 (1.04-1.79)1.35 (1.03-1.76)1.04 (0.74-1.46)
        30+17 (3.7)15 (2.8)29 (2.0)1.92 (1.02-3.63)1.78 (0.90-3.53)1.14 (0.52-2.48)
    Weight gain since age 20 y
        Weight loss25 (5.4)26 (4.9)86 (5.9)1.07 (0.63-1.82)0.92 (0.55-1.56)1.05 (0.52-2.12)
        1-5 kg79 (17.1)81 (15.1)296 (20.2)111
        6-10 kg66 (14.3)78 (14.6)269 (18.4)0.98 (0.67-1.43)1.05 (0.73-1.52)1.00 (0.60-1.64)
        11-20 kg121 (26.3)149 (27.9)443 (30.2)1.10 (0.79-1.53)1.19 (0.86-1.63)1.08 (0.70-1.67)
        21+ kg130 (28.2)149 (27.9)305 (20.8)1.72 (1.22-2.41)1.65 (1.18-2.29)1.11 (0.72-1.71)
    Height (m)
        <1.6519 (4.1)24 (4.5)54 (3.7)111
        1.75 > height ≥ 1.65138 (29.9)174 (32.5)490 (33.5)0.86 (0.48-1.52)0.86 (0.51-1.47)0.92 (0.47-1.80)
        1.85 > height ≥ 1.75239 (51.8)264 (49.4)739 (50.4)1.03 (0.59-1.82)0.94 (0.55-1.58)0.95 (0.49-1.84)
        ≥1.8555 (11.9)66 (12.3)175 (12.0)0.97 (0.52-1.81)1.00 (0.55-1.80)0.80 (0.38-1.70)
  • NOTE: Some counts do not add to totals because of missing and omitted information.

    Abbreviations: ORadj, adjusted odds ratio; High/Int, Amsterdam or Bethesda criteria for family history of CRC.

  • * Adjusted for age, province, history of hypercholesterolemia/hypertriglyceridemia, education, and history of colon screening endoscopy.