Table 3.

Counts and risk estimates among women for BMI, weight gain, and height in relation to incident CRC, stratified by estrogen status

MeasureCases, n (%)Controls, n (%)Age-adjusted OR (95% CI)Multivariable adjusted OR (95% CI)*
Estrogen-positive women
    BMI 2 y ago (kg/m2)
        18.5-24.99260 (51.3)243 (50.0)11
        25-29.99148 (29.2)143 (29.4)1.00 (0.75-1.34)0.89 (0.66-1.21)
        30+80 (15.8)86 (17.7)0.84 (0.59-1.21)0.67 (0.45-0.98)
    BMI at age 20 y (kg/m2)
        18.5-24.99351 (69.2)366 (75.3)11
        25-29.9940 (7.9)38 (7.8)1.06 (0.66-1.71)1.06 (0.64-1.76)
        30+15 (3.0)14 (2.9)1.03 (0.49-2.18)0.74 (0.33-1.67)
    Weight gain since age 20 y
        Weight loss30 (5.9)41 (8.4)0.82 (0.48-1.42)0.86 (0.49-1.50)
        1-5 kg107 (21.1)116 (23.9)11
        6-10 kg97 (19.1)89 (18.3)1.17 (0.79-1.74)1.16 (0.77-1.74)
        11-20 kg144 (28.4)139 (28.6)1.18 (0.82-1.69)1.09 (0.75-1.58)
        21+ kg102 (20.1)91 (18.7)1.25 (0.84-1.85)1.04 (0.68-1.58)
    Height (m)
        <1.5551 (10.1)79 (16.3)11
        1.65 > height ≥ 1.55226 (44.6)210 (43.2)1.62 (1.08-2.42)1.71 (1.12-2.62)
        175 > height ≥ 1.65200 (39.5)179 (36.8)1.68 (1.11-2.53)1.84 (1.10-2.84)
        ≥1.75 m28 (5.5)18 (3.7)2.31 (1.15-4.65)2.54 (1.23-5.25)
Estrogen-negative women
    BMI 2 y ago (kg/m2)
        18.5-24.99356 (39.7)302 (42.1)11
        25-29.99295 (32.9)241 (33.6)1.09 (0.86-1.37)1.08 (0.85-1.37)
        30+180 (20.1)138 (19.3)1.12 (0.85-1.48)1.05 (0.79-1.40)
    BMI at age 20 y (kg/m2)
        18.5-24.99645 (71.9)509 (71.0)11
        25-29.9960 (6.7)54 (7.5)0.86 (0.58-1.27)0.81 (0.54-1.21)
        30+23 (2.6)13 (1.8)1.15 (0.56-2.35)1.08 (0.52-2.27)
    Weight gain since age 20 y
        Weight loss77 (8.6)44 (6.1)1.44 (0.92-2.25)1.45 (0.92-2.29)
        1-5 kg151 (16.8)127 (17.7)11
        6-10 kg131 (14.6)121 (16.9)0.96 (0.68-1.36)1.04 (0.73-1.48)
        11-20 kg242 (27.0)210 (29.3)1.02 (0.75-1.39)1.08 (0.79-1.48)
        21+ kg210 (23.4)167 (23.3)1.11 (0.81-1.53)1.13 (0.82-1.58)
    Height (m)
        <1.55133 (14.8)141 (19.7)11
        1.65 > height ≥ 1.55407 (45.4)318 (44.4)1.36 (1.03-1.80)1.40 (1.05-1.87)
        175 > height ≥ 1.65297 (33.1)230 (32.1)1.35 (1.00-1.81)1.42 (1.05-1.93)
        ≥1.7551 (5.7)24 (3.4)2.23 (1.29-3.86)2.31 (1.31-4.07)
  • NOTE: Some counts do not add to totals because of missing and omitted information.

  • * Adjusted for age, education, red meat, physical activity, province of residence, CRC screening endoscopy, history of high cholesterol/triglycerides, and hormonal contraceptive use.

  • Estrogen positive: premenopausal or postmenopausal taking postmenopausal hormone therapy; estrogen negative: postmenopausal, not taking hormone therapy.