Table 4.

Concentrations [geometric mean (95% confidence intervals)] and percentage changes from cycle 1 (baseline) to cycle 5 in serum androgens in the early follicular and late follicular phases of the menstrual cycle, by study arm

Early follicular
Late follicular
Cycle 1, mean (95% CI)Cycle 5, mean (95% CI)% ChangeP*Cycle 1, mean (95% CI)Cycle 5, mean (95% CI)% ChangeP*
DHEA (ng/mL)
    Botanical (n = 13)5.22 (3.99-6.83)4.53 (3.62-6.14)−13.220.0164.81 (3.82-6.07)4.81 (3.96-5.84)0.000.981
    Diet (n = 10)5.38 (3.60-8.04)4.41 (2.75-7.08)−18.030.1114.60 (3.21-6.60)4.78 (3.27-6.99)3.910.521
    Placebo (n = 12)3.81 (2.46-5.89)4.14 (2.84-6.02)8.663.75 (2.65-5.29)3.76 (2.73-5.17)0.27
DHEAS (μg/dL)
    Botanical (n = 13)144 (123-170)123 (106-143)−14.580.065148 (122-180)122 (102-145)−17.570.161
    Diet (n = 10)133 (105-168)130 (96-176)−2.260.947135 (109-167)134 (101-178)−0.740.564
    Placebo (n = 12)121 (69-213)121 (73-202)0.00129 (78-213)121 (75-196)−6.20
Androstenedione (ng/mL)
    Botanical (n = 13)1.28 (1.02-1.60)1.17 (0.94-1.45)−8.590.0531.59 (1.33-1.90)1.47 (1.23-1.76)−7.550.492
    Diet (n = 10)1.28 (0.99-1.67)1.19 (0.85-1.68)−7.030.2401.40 (1.08-1.83)1.45 (1.16-1.80)3.570.848
    Placebo (n = 12)1.03 (0.81-1.31)1.14 (0.88-1.46)10.681.26 (1.06-1.50)1.26 (1.10-1.57)0.00
Total testosterone (ng/dL)
    Botanical (n = 13)31.6 (27.3-36.6)28.3 (23.2-34.5)−10.440.14536.2 (32.3-40.5)37.2 (32.1-43.0)2.760.871
    Diet (n = 10)28.3 (22.5-35.6)28.1 (1.90-4.17)−0.710.82631.7 (25.5-39.5)32.1 (25.4-40.5)1.260.806
    Placebo (n = 12)25.1 (20.5-30.6)26.2 (20.4-33.7)4.3829.4 (24.6-35.1)30.7 (25.0-37.6)4.42
Free testosterone (pg/mL)
    Botanical (n = 13)4.51 (3.77-5.39)4.05 (3.22-5.10)−10.200.1895.60 (4.67-6.70)5.23 (4.38-6.25)−6.610.438
    Diet (n = 10)5.21 (4.13-6.58)4.84 (3.60-6.49)−7.100.5945.83 (4.64-7.32)5.71 (4.69-6.95)−2.060.885
    Placebo (n = 12)4.38 (3.37-5.71)4.63 (3.64-5.89)5.715.50 (4.52-6.70)5.51 (4.40-6.89)0.18
  • Abbreviation: DHEA, dehydroepiandrosterone.

  • * Comparing change between cycles 1 and 5 in botanical or diet arms versus change in placebo using paired t tests with unequal variances.

  • Baseline total testosterone significantly higher in botanical arm versus placebo arm (P = 0.01).