Table 2.

Self-reported side effects rated as moderate or severe during menstrual cycles 2 to 5

SymptomBotanical supplement, n (%)
Dietary changes, n (%)
Placebo, n (%)
n = 15n = 10n = 15
Gastrointestinal symptoms
    Gas/bloating6 (40.0)5 (50.0)5 (33.3)
    Increased bowel movements/diarrhea2 (13.3)5 (50.0)6 (40.0)
    Indigestion5 (33.3)*1 (10.0)0 (0)
    Loss of appetite1 (6.7)1 (10.0)1 (6.7)
    Nausea0 (0)0 (0)0 (0)
    Stomach pain1 (6.7)1 (10.0)2 (13.3)
Neurologic symptoms
    Changes in sleep4 (26.7)5 (50.0)5 (33.3)
    Dizziness1 (6.7)0 (0)0 (0)
    Headache1 (6.7)2 (20.0)3 (20.0)
Dermatologic symptoms
    Hives/itching/skin rash2 (13.3)0 (0)5 (33.3)
  • * P = 0.014 when compared with placebo.