Table 2.

Weighted summary statistics for serum androgen levels by 4-wk history of statin use (yes versus no) among men providing blood samples in BACH Survey, 2002-2005, N = 1,812

OutcomeEstimatesTotal (N = 1,812)Statin use, yes (n = 237)Statin use, no* (n = 1,575)P
TT (ng/dL)Adjusted mean (SE)439.1 (7.8)394.3 (16.0)445.3 (8.1)0.004
Crude mean (SE)439.1 (7.8)382.1 (14.2)447.2 (8.6)0.0005
Median (IQR)§417.3 (248.9)362.3 (186.1)423.5 (255.7)
FT (ng/dL)Adjusted mean (SE)9.1 (0.2)8.6 (0.3)9.2 (0.2)0.11
Crude mean (SE)9.1 (0.2)7.4 (0.2)9.4 (0.2)<0.0001
Median (IQR)8.6 (4.6)7.3 (2.9)8.9 (4.6)
SHBG (nmol/L)Adjusted mean (SE)33.7 (0.6)28.8 (1.8)34.4 (0.6)0.01
Crude mean (SE)33.7 (0.6)35.3 (1.5)33.5 (0.7)0.15
Median (IQR)29.9 (19.1)33.8 (19.5)29.5 (19.1)
DHEAS (μg/mL)Adjusted mean (SE)2.0 (0.1)1.9 (0.1)2.1 (0.04)0.06
Crude mean (SE)2.0 (0.1)1.4 (0.1)2.1 (0.1)<0.0001
Median (IQR)1.9 (1.5)1.1 (1.0)2.0 (1.5)
LH (IU/L)Adjusted mean (SE)5.4 (0.1)5.6 (0.4)5.3 (0.1)0.98
Mean (SE)5.4 (0.1)6.1 (0.4)5.3 (0.1)0.18
Median (IQR)4.7 (2.8)5.0 (3.0)4.7 (2.8)
  • NOTE: Adjusted means and SEs are adjusted for age and the time between awakening and having blood drawn. Of 2,301 men in the BACH study, 42 men were excluded from the analysis for taking medications likely to affect androgen levels or because they were under current treatment for cancer (29 men). Three hundred ninety-six men had missing values for hormones, and 22 men had hormone values more than 4 SDs from the mean of the natural log distribution and were excluded as outliers.

  • * n for nonusers of statins was 1,575 for TT and 1,574 for the other four hormones.

  • P value for t test of differences in means (on natural log scale) comparing statin use with no use.

  • Metric units in nanograms per deciliter can be divided by 28.84 to obtain Systeme International units, nanomoles per liter.

  • § IQR (calculated as the 75% percentile minus the 25% percentile).

  • Metric units in micrograms per deciliter can be multiplied by 0.02714 to obtain Systeme International units, micromoles per liter.