Table 2.

Multivariate analysis of lymphoma and total serum IgE

Total population, N (%)1st tertile (0.00-2.96 kU/L)*
2nd tertile (2.96-4.18 kU/L)*
3rd tertile (4.18-7.61 kU/L)*
n (%)N (%)OR (95% CI)N (%)OR (95% CI)
Control537 (53.5)177 (32.0)179 (33.3)181 (33.7)
All lymphomas466 (46.5)240 (51.5)Reference127 (27.7)0.55 (0.40-0.74)97 (20.8)0.39 (0.28-0.54)
Lymphoma subgroups
    NHL246 (53.0)108 (43.9)Reference77 (31.3)0.72 (0.49-1.03)61 (24.8)0.54 (0.36-0.81)
    B cell384 (82.4)209 (54.4)Reference109 (28.4)0.54 (0.40-0.75)66 (17.2)0.34 (0.23-0.48)
        CLL104 (22.3)72 (69.2)Reference25 (24.0)0.34 (0.20-0.57)7 (6.7)0.10 (0.04-0.22)
        Lymphoplasmatic lymphoma19 (4.1)11 (57.9)Reference3 (15.8)0.28 (0.07-1.06)5 (26.3)0.48 (0.15-1.49)
        Splenic marginal zone23 (4.9)12 (52.2)Reference6 (26.1)0.55 (0.19-1.59)5 (21.7)0.47 (0.15-1.46)
        Plasma cell myeloma68 (14.6)44 (64.7)Reference15 (22.1)0.38 (0.20-0.71)9 (13.2)0.24 (0.11-0.53)
        Marginal zone B cell23 (4.9)9 (39.1)Reference7 (30.4)0.93 (0.32-2.67)7 (30.4)0.93 (0.31-2.78)
        Follicular lymphoma36 (7.7)19 (52.8)Reference13 (36.1)0.67 (0.31-1.47)4 (11.1)0.18 (0.06-0.56)
        Diffuse large-cell lymphoma79 (16.9)32 (40.5)Reference29 (36.7)0.94 (0.53-1.65)18 (22.8)0.60 (0.31-1.15)
        Other B-cell lymphoma32 (6.9)10 (31.3)Reference11 (34.4)0.95 (0.38-2.37)11 (34.4)0.97 (0.38-2.47)
    HL48 (10.3)16 (33.3)Reference12 (25.0)0.57 (0.25-1.31)20 (41.7)0.72 (0.33-1.54)
    T-cell lymphoma34 (7.3)15 (44.1)Reference8 (23.5)0.47 (0.19-1.17)11 (32.4)0.49 (0.20-1.20)
        Mycosis fungoides/Sézary16 (3.4)7 (43.8)Reference4 (25.0)0.51 (0.14-1.89)5 (31.3)0.43 (0.11-1.65)
        Other T cell18 (3.9)8 (44.4)Reference4 (22.2)0.47 (0.13-1.63)6 (33.3)0.54 (0.16-1.79)
  • NOTE: Adjusted for age, sex, center, smoking status, any treated asthma or eczema.

  • * Tertiles were defined as follows: 1st tertile (reference category), 0.00 to 2.96 kU/L; 2nd tertile, 2.96 to 4.18 kU/L; 3rd tertile, 4.18 to 7.61 kU/L (using log-transformed total IgE data).

  • NHL category excludes CLL, MM, and HL.