OR and 95% CI of kidney cancer for family history of cancer
| Overall | Young onset (≤50) | Old onset (>50) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95%CI) | Case | Control | OR (95%CI) | Case | Control | OR (95%CI) | ||||||||||
| Type of cancer | ||||||||||||||||||
| No FH of any cancer | 725 | 1,094 | 1.00 (reference) | 146 | 238 | 1.00 (reference) | 579 | 856 | 1.00 (reference) | |||||||||
| With FH of any cancer | 370 | 454 | 1.17 (0.99-1.39) | 66 | 67 | 1.55 (1.03-2.33) | 304 | 387 | 1.10 (0.92-1.33) | |||||||||
| With FH of kidney cancer | 18 | 17 | 1.40 (0.71-2.76) | 5 | 1 | 9.03 (1.00-81.5) | 13 | 16 | 1.04 (0.49-2.20) | |||||||||
| No. first-degree relatives with family history of any cancer | ||||||||||||||||||
| 0 | 725 | 1,094 | 1.00 (reference) | 146 | 238 | 1.00 (reference) | 579 | 856 | 1.00 (reference) | |||||||||
| 1 | 301 | 379 | 1.14 (0.95-1.37) | 56 | 62 | 1.40 (0.91-2.16) | 245 | 317 | 1.08 (0.89-1.33) | |||||||||
| ≥2 | 69 | 75 | 1.32 (0.93-1.87) | 10 | 5 | 3.34 (1.10-10.2) | 59 | 70 | 1.19 (0.83-1.73) | |||||||||
| Trend | 1.15 (1.00-1.31) | 1.55 (1.09-2.20) | 1.09 (0.94-1.26) | |||||||||||||||
| No. of first degree relatives with family history of kidney cancer | ||||||||||||||||||
| 0 | 736 | 1,125 | 1.00 (reference) | 148 | 245 | 1.00 (reference) | 588 | 880 | 1.00 (reference) | |||||||||
| 1 | 16 | 16 | 1.33 (0.65-2.70) | 4 | 1 | 6.82 (0.72-64.57) | 12 | 15 | 1.05 (0.48-2.27) | |||||||||
| 2 | 2 | 1 | 2.80 (0.25-31.6) | 1 | 0 | — | 1 | 1 | 1.20 (0.07-19.5) | |||||||||
| Trend | 1.41 (0.77-2.59) | 7.53 (0.91-62.40) | 1.06 (0.54-2.09) | |||||||||||||||
| Parental family history | ||||||||||||||||||
| No FH of any cancer | 725 | 1,094 | 1.00 (reference) | 146 | 238 | 1.00 (reference) | 579 | 856 | 1.00 (reference) | |||||||||
| With FH of any cancer | 291 | 361 | 1.16 (0.96-1.39) | 60 | 56 | 1.70 (1.10-2.62) | 231 | 305 | 1.06 (0.87-1.31) | |||||||||
| With FH of kidney cancer | 10 | 15 | 0.86 (0.38-1.95) | 5 | 1 | 9.03 (1.00-81.5) | 5 | 14 | 0.45 (0.16-1.26) | |||||||||
| Sibling family history* | ||||||||||||||||||
| No FH of any cancer | 611 | 930 | 1.00 (reference) | 126 | 205 | 1.00 (reference) | 485 | 725 | 1.00 (reference) | |||||||||
| With FH of any cancer | 98 | 120 | 1.17 (0.87-1.57) | 9 | 10 | 1.31 (0.51-3.41) | 89 | 110 | 1.16 (0.85-1.59) | |||||||||
| With FH of kidney cancer | 9 | 3 | 4.09 (1.09-15.4) | 1 | 0 | — | 8 | 3 | 3.48 (0.90-13.4) | |||||||||
| Offspring family history† | ||||||||||||||||||
| No FH of any cancer | 647 | 983 | 1.00 (reference) | 123 | 208 | 1.00 (reference) | 524 | 775 | 1.00 (reference) | |||||||||
| With FH of any cancer | 14 | 8 | 2.24 (0.92-5.43) | 2 | 2 | 2.18 (0.28-16.7) | 12 | 6 | 2.47 (0.91-6.74) | |||||||||
| With FH of kidney cancer | 0 | 0 | 0 | 0 | — | 0 | 0 | — | ||||||||||