Table 2.

OR and 95% CI of kidney cancer for family history of cancer

Overall
Young onset (≤50)
Old onset (>50)
CaseControlOR (95%CI)CaseControlOR (95%CI)CaseControlOR (95%CI)
Type of cancer
    No FH of any cancer7251,0941.00 (reference)1462381.00 (reference)5798561.00 (reference)
    With FH of any cancer3704541.17 (0.99-1.39)66671.55 (1.03-2.33)3043871.10 (0.92-1.33)
    With FH of kidney cancer18171.40 (0.71-2.76)519.03 (1.00-81.5)13161.04 (0.49-2.20)
No. first-degree relatives with family history of any cancer
    07251,0941.00 (reference)1462381.00 (reference)5798561.00 (reference)
    13013791.14 (0.95-1.37)56621.40 (0.91-2.16)2453171.08 (0.89-1.33)
    ≥269751.32 (0.93-1.87)1053.34 (1.10-10.2)59701.19 (0.83-1.73)
    Trend1.15 (1.00-1.31)1.55 (1.09-2.20)1.09 (0.94-1.26)
No. of first degree relatives with family history of kidney cancer
    07361,1251.00 (reference)1482451.00 (reference)5888801.00 (reference)
    116161.33 (0.65-2.70)416.82 (0.72-64.57)12151.05 (0.48-2.27)
    2212.80 (0.25-31.6)10111.20 (0.07-19.5)
    Trend1.41 (0.77-2.59)7.53 (0.91-62.40)1.06 (0.54-2.09)
Parental family history
    No FH of any cancer7251,0941.00 (reference)1462381.00 (reference)5798561.00 (reference)
    With FH of any cancer2913611.16 (0.96-1.39)60561.70 (1.10-2.62)2313051.06 (0.87-1.31)
    With FH of kidney cancer10150.86 (0.38-1.95)519.03 (1.00-81.5)5140.45 (0.16-1.26)
Sibling family history*
    No FH of any cancer6119301.00 (reference)1262051.00 (reference)4857251.00 (reference)
    With FH of any cancer981201.17 (0.87-1.57)9101.31 (0.51-3.41)891101.16 (0.85-1.59)
    With FH of kidney cancer934.09 (1.09-15.4)10833.48 (0.90-13.4)
Offspring family history
    No FH of any cancer6479831.00 (reference)1232081.00 (reference)5247751.00 (reference)
    With FH of any cancer1482.24 (0.92-5.43)222.18 (0.28-16.7)1262.47 (0.91-6.74)
    With FH of kidney cancer000000
  • NOTE: OR is adjusted for age, sex, country, smoking pack-years, body mass index, and medical history of hypertension.

    Abbreviation: FH, family history of first-degree relatives.

  • * Restricted to those who had siblings.

  • Restricted to those who had offspring.