Table 2.

Relationship of HBV DNA and ALT to serum and RBC folate levels

nHBV DNA* (copies/mL)
ALT (IU/L)
OR (95% CI)PtrendOR (95% CI)Ptrend
Serum folate-all (μg/L)
    Q1: <7.5526Referent0.12Referent0.002
    Q2: 7.5-10.45561.33 (0.73-2.42)1.02 (0.91-1.15)
    Q3: 10.5-14.45611.39 (0.72-2.67)0.89 (0.79-1.00)
    Q4: ≥14.55141.70 (0.87-3.33)0.86 (0.76-0.97)
Serum folate-women (μg/L)
    Q1: <7.5273Referent0.22Referent0.004
    Q2: 7.5-10.43221.43 (0.39-2.57)1.03 (0.86-1.24)
    Q3: 10.5-14.43071.55 (0.28-2.91)0.85 (0.73-0.99)
    Q4: ≥14.52841.61 (0.17-3.16)0.85 (0.72-1.01)
Serum folate-men (μg/L)
    Q1: <7.5240Referent0.85Referent0.04
    Q2: 7.5-10.42170.81 (0.38-1.73)0.99 (0.85-1.16)
    Q3: 10.5-14.42810.86 (0.39-1.89)0.91 (0.77-1.08)
    Q4: ≥14.52330.90 (0.41-2.00)0.83 (0.70-1.00)
RBC folate-all (μg/L)
    Q1: <320578Referent0.68Referent0.92
    Q2: 320-3994920.55 (0.28-1.07)1.02 (0.87-1.20)
    Q3: 400-4996120.92 (0.49-1.75)1.02 (0.88-1.19)
    Q4: ≥5004750.73 (0.35-1.54)0.97 (0.79-1.20)
RBC folate-women (μg/L)
    Q1: <320327Referent0.91Referent0.65
    Q2: 320-3992860.84 (0.26-2.69)1.06 (0.88-1.29)
    Q3: 400-4992960.95 (0.28-3.18)0.94 (0.79-1.12)
    Q4: ≥5002770.90 (0.27-2.96)1.01 (0.85-1.20)
RBC folate-men (μg/L)
    Q1: <320248Referent0.82Referent0.92
    Q2: 320-3992460.66 (0.30-1.45)1.02 (0.87-1.20)
    Q3: 400-4992410.51 (0.21-1.23)1.02 (0.88-1.19)
    Q4: ≥5002361.01 (0.46-2.21)0.97 (0.79-1.20)
  • Abbreviations: Q, quartile; OR, odds ratio.

  • * Adjusted for year, age, sex, smoking and drinking status, and ALT.

  • Adjusted for sex, age, smoking, alcohol consumption, and presence of HBV DNA.