Table 6.

Joint effect of the GSTO1 genotypes/diplotypes and arsenic exposure on risk of skin lesions

GSTO1 genotype/diplotypeJoint effect of GSTO1 genotype/diplotype and time-weighted well arsenic concentration
Joint effect of GSTO1 genotype/diplotype and urinary %MMA
TWA levelsMeans of TWAn (cases/controls)Adjusted ORs for skin lesions*P for interaction%MMAMeans of %MMAn (cases/controls)Adjusted ORs for skin lesionsP for interaction
GSTO1 (rs4925)
    CC<7326.19145/3441.000.99<139.53133/3541.000.07
    CA<7326.9451/1470.93 (0.61-1.42)<139.3864/1581.11 (0.73-1.67)
    AA<7331.7510/181.98 (0.79-4.93)<139.6212/172.89 (1.18-7.08)
    CC≥73207.47222/2682.08 (1.54-2.82)≥1317.34244/2791.31 (0.87-1.96)
    CA≥73205.2296/1142.32 (1.58-3.41)≥1317.3485/1121.43 (1.05-1.94)
    AA≥73159.2514/93.39 (1.29-8.88)≥1316.3512/131.63 (0.66-4.00)
GSTO1 (rs11509437)
    TT/AT<7322.8131/941.000.40<139.2633/971.000.05
    AA<7327.45171/3861.51 (0.96-2.36)<139.51173/3981.50 (0.95-2.37)
    TT/AT≥73201.4653/702.89 (1.70-4.92)≥1317.0853/741.73 (1.01-2.97)
    AA≥73207.72272/3013.31 (2.13-5.16)≥1317.32280/3151.88 (1.20-2.95)
GSTO1 (rs11509438)
    AA/GA<7323.4535/981.000.59<139.2433/1101.000.02
    GG<7327.53170/3951.27 (0.81-1.98)<139.57171/3951.58 (0.99-2.52)
    AA/GA≥73199.1452/762.32 (1.34-4.01)≥1317.2556/711.96 (1.11-3.45)
    GG≥73205.17270/3012.83 (1.82-4.39)≥1317.26279/3271.85 (1.17-2.91)
GSTO1 diplotypes
    Other/other<7326.42132/3081.000.83<139.57122/3101.000.08
    AAG/other<7326.6651/1241.12 (0.74-1.69)<139.3062/1351.22 (0.81-185)
    AAG/AAG<7334.089/171.94 (0.78-4.85)<139.5712/162.64 (1.08-6.45)
    Other/other≥73207.17203/2392.24 (1.66-3.03)≥1317.35223/2581.50 (1.11-2.03)
    AAG/other≥73206.9685/1022.30 (1.56-3.39)≥1317.1776/991.39 (0.93-2.08)
    AAG/AAG≥73164.5113/83.38 (1.30-8.79)≥1316.2010/121.61 (0.64-4.05)
  • * ORs were adjusted for age and gender, smoking status, BMI, and water consumption per day.

  • ORs were adjusted for age and gender, smoking status, BMI, water consumption per day, and well arsenic concentration.