Table 6.

Summary of MDR1 G2677/T/A allele frequencies reported in various studies

StudynRacial groupMethodsAllele frequencies
GTA
Healthy population
Cascorbi et al. 2001461 (167 ♀, 294 ♂)GermanRFLP and sequencing0.5640.4160.019
Kurzawski et al. 2006204 (♀ 93, ♂ 111)Polish-CaucasianAllele-specific PCR and sequencing0.5950.3850.020
Gaikovitch et al. 2003290 (healthy or non malignant disease)Russian-CaucasianHybridization probe0.5480.4190.033
Allabi et al. 2005111West African (Beninese)2× sequencing0.9910.0090
Cavaco et al. 2003100Caucasian PortuguesePCR-RFLP0.5250.475
Tan et al. 2004104ChineseSequencing0.5050.4370.058
139Polish Caucasians0.5760.4140.011
Tang et al. 2002104ChineseRFLP0.5050.4370.058
93Malay0.5750.3600.065
68Indian0.3380.6180.044
Lee et al. 2005632KoreansPyrosequencing0.4380.3910.171
142Vietnamese0.5810.3560.063
Horinouchi et al. 2002117JapanesePCR-RFLP and sequencing0.4400.3600.200
Saito et al. 2003130 (♀ 70, ♂ 60)JapaneseTaqman and direct sequencing?0.4320.4080.169
IBD studies
Urcelay et al. 2006321 CDSpanishPCR and sequencing0.6320.3590.009
330 UC0.6280.3650.007
352 controls0.6050.3840.011
Potocnik et al. 2004139 CDSlovenianTaqman0.5950.405
144 UC0.5200.480
355 controls0.5970.403
Onnie et al. 2006828 CDBritish (Jewish and non-Jewish)Pyrosequencing and partial sequencing (48 samples)0.5790.4050.016
580 UC0.5330.4460.021
285 controls0.5790.3960.025
Ho et al. 2005335 UC patientsScottishTaqman (only G/T) and sequencing (100) for A allele frequency0.5460.4980.02
268 CD patients0.5280.472
370 controls0.5120.498
Palmieri et al. 2005478 CD patientsItalianSequencing0.5590.4250.016
468 UC patients0.5280.4470.025
450 controls0.5560.4230.021
Brant et al. 2003211 non-Jewish IBD65% non-Jewish0.602 NJP0.393 NJP0.005 NJP
392 non-Jewish controls0.524 NJC0.45 NJC0.026 NJC
114 Jewish IBDPCR-sequencing and pyrosequencing0.627 JP0.368 JP0.005 JP
219 White Ashkenazi Jewish controls35% Jewish ancestry0.605 JC0.365 JC0.003 JC
  • NOTE: ♀, male; ♂, female.

    Abbreviations: CD, Crohn's disease; UC, ulcerative colitis; NJP, non-Jewish IBD patients; NJC, non-Jewish controls; JP, Jewish IBD patients; JC, white Ashkenazi Jewish controls.