Table 4.

Detection of DNA hypermethylation and/or high-risk HPV DNA in urine samples from women with and without biopsy-confirmed cervical neoplasia

Negative and atypical (n = 19)CIN-1 (n = 9)CIN-2–3 and CIS (n = 29)ICC (n = 72)P*
Urine HPV5/19 (26%)5/9 (56%)22/29 (76%)56/71 (79%)<0.0001
Urine HR-HPV2/19 (11%)4/9 (44%)17/29 (59%)50/71 (70%)<0.0001
Urine—any hypermethylation1/16 (6%)0/9 (0%)7/25 (28%)39/63 (62%)<0.0001
Urine HR-HPV or any hypermethylation3/16 (19%)4/9 (44%)16/25 (64%)52/62 (84%)<0.0001
Urine HR-HPV and any hypermethylation0/16 (0%)0/9 (0%)5/25 (20%)33/62 (53%)<0.0001
  • * Mantel-Haenszel test for trend.