Table 3.

Detection of hypermethylation of DAPK1, RARB, TWIST, and CDH13 in urine samples from women with and without biopsy-confirmed cervical neoplasia

Negative and atypical (n = 16)CIN-1 (n = 9)CIN-2–3 and CIS (n = 25)ICC (n = 63)P*
DAPK11/16 (6%)0/9 (0%)7/25 (28%)31/63 (49%)0.0001
RARB1/16 (6%)0/9 (0%)1/25 (4%)25/63 (40%)0.0006
TWIST1/16 (6%)0/9 (0%)1/25 (4%)20/63 (32%)0.0046
CDH130/16 (0%)0/9 (0%)1/25 (4%)6/63 (10%)0.1044
DAPK1, RARB, or TWIST1/16 (6%)0/9 (0%)7/25 (28%)39/63 (62%)<0.0001
DAPK1, RARB, TWIST, or CDH131/16 (6%)0/9 (0%)7/25 (28%)39/63 (62%)<0.0001
  • * Mantel-Haenszel test for trend.