Analysis of MDR1 SNPs and risk of childhood ALL
| Genotype | Cases (n = 294) | Controls (n = 369) | OR (95% CI)* | |||
|---|---|---|---|---|---|---|
| T−129C | ||||||
| TT | 253 (89.7) | 330 (90.9) | 1.00 (Reference) | |||
| TC | 27 (9.6) | 32 (8.8) | 1.09 (0.62-1.93) | |||
| CC | 2 (0.7) | 1 (0.3) | 2.68 (0.23-30.96) | |||
| TC + CC | 29 (10.3) | 33 (9.1) | 1.12 (0.64-1.97) | |||
| C1236T | ||||||
| CC | 73 (25.7) | 97 (26.6) | 1.00 (Reference) | |||
| CT | 144 (50.7) | 199 (54.5) | 0.90 (0.61-1.33) | |||
| TT | 67 (23.6) | 69 (18.9) | 1.15 (0.73-1.81) | |||
| CT + TT | 211 (74.3) | 268 (73.4) | 0.97 (0.67-1.40) | |||
| G2677T/A | ||||||
| GG | 79 (28.2) | 104 (28.8) | 1.00 (Reference) | |||
| GT or GA | 144 (51.4) | 192 (53.2) | 1.01 (0.70-1.46) | |||
| TA, TT, or AA | 57 (20.4) | 65 (18.0) | 1.26 (0.78-2.05) | |||
| Non-GG | 201 (71.8) | 257 (71.2) | 1.06 (0.74-1.51) | |||
| C3435T | ||||||
| CC | 81 (27.6) | 100 (27.1) | 1.00 (Reference) | |||
| CT | 140 (47.6) | 178 (48.2) | 0.98 (0.67-1.42) | |||
| TT | 73 (24.8) | 91 (24.7) | 0.99 (0.65-1.49) | |||
| CT + TT | 213 (72.4) | 269 (72.9) | 0.98 (0.69-1.39) | |||
↵* ORs and 95% CI were calculated using conditional logistic regression (matching factors: date of birth, sex, Hispanic status, and maternal race).