Table 2.

Analysis of MDR1 SNPs and risk of childhood ALL

GenotypeCases (n = 294)Controls (n = 369)OR (95% CI)*
T−129C
    TT253 (89.7)330 (90.9)1.00 (Reference)
    TC27 (9.6)32 (8.8)1.09 (0.62-1.93)
    CC2 (0.7)1 (0.3)2.68 (0.23-30.96)
    TC + CC29 (10.3)33 (9.1)1.12 (0.64-1.97)
C1236T
    CC73 (25.7)97 (26.6)1.00 (Reference)
    CT144 (50.7)199 (54.5)0.90 (0.61-1.33)
    TT67 (23.6)69 (18.9)1.15 (0.73-1.81)
    CT + TT211 (74.3)268 (73.4)0.97 (0.67-1.40)
G2677T/A
    GG79 (28.2)104 (28.8)1.00 (Reference)
    GT or GA144 (51.4)192 (53.2)1.01 (0.70-1.46)
    TA, TT, or AA57 (20.4)65 (18.0)1.26 (0.78-2.05)
    Non-GG201 (71.8)257 (71.2)1.06 (0.74-1.51)
C3435T
    CC81 (27.6)100 (27.1)1.00 (Reference)
    CT140 (47.6)178 (48.2)0.98 (0.67-1.42)
    TT73 (24.8)91 (24.7)0.99 (0.65-1.49)
    CT + TT213 (72.4)269 (72.9)0.98 (0.69-1.39)
  • * ORs and 95% CI were calculated using conditional logistic regression (matching factors: date of birth, sex, Hispanic status, and maternal race).