Table 5.

Influence of dietary factors on the association of the MTHFR C677C, A1298C and FTHFD rs2002287 (T/C) SNPs with breast cancer

Dietary folate
<Median
≥Median*
GenotypeNo. cases/controlOR (95% CI)No. cases/controlOR (95% CI)
MTHFR C677T
    CC100/1161.00 (reference)103/1081.00 (reference)
    CT + TT124/1211.17 (0.84-1.63)145/1291.23 (0.91-1.88)
Pinteraction = 0.48
Total folate
<Median
≥Median*
Genotype
No. cases/control
OR (95% CI)
No. cases/control
OR (95% CI)
MTHFR C677T
    CC95/1161.00 (reference)108/1081.00 (reference)
    CT + TT110/1201.08 (0.77-1.52)159/1301.31 (0.97-1.78)
Pinteraction = 0.067
MTHFR A1298C
    AA98/1171.00 (reference)113/1261.00 (reference)
    AC + CC106/1201.05 (0.75-1.48)155/1111.53 (1.12-2.09)
Pinteraction = 0.03
Alcohol intake
None
Any
Genotype
No. cases/control
OR (95% CI)
No. cases/control
OR (95% CI)
MTHFR A1298C
    AA132/1221.00 (reference)92/1301.00 (reference)
    AC + CC154/1450.96 (0.68-1,36)116/961.70 (1.15-2.52)
Pinteraction = 0.03
Methionine intake
<Median
≥Median*
Genotype
No. cases/control
OR (95% CI)
No. cases/control
OR (95% CI)
FTHFD rs2002287 (T/C)
    TT107/901.00 (reference)104/871.00 (reference)
    CT + CC141/1430.83 (0.60-1.15)119/1540.62 (0.45-0.85)
Pinteraction = 0.035
  • * Above median groups include any individuals whose values are at the median.

  • ORs were calculated using unconditional logistic regression adjusting for age, race, date of blood draw, history of breast cyst, hormone replacement therapy, and parity.