Table 4.

Combined effect of genotypes from protective or risk alleles on the risk of breast cancer in all cases

Allele type/numberCasesControlsOR* (95% CI)OR (95% CI)
Protective
    099771.00 (reference)1.00 (reference)
    11871640.87 (0.60-1.27)0.89 (0.61-1.30)
    21301470.67 (0.46-1.00)0.70 (0.47-1.04)
    350700.58 (0.36-0.94)0.64 (0.39-1.05)
    48110.63 (0.24-1.66)0.70 (0.26-1.89)
Ptrend = 0.008Ptrend = 0.029
Risk§
    0 + 11321831.00 (reference)1.00 (reference)
    21781721.49 (1.08-2.04)1.44 (1.05-1.98)
    3129941.89 (1.31-2.71)1.83 (1.27-2.64)
    433241.93 (1.07-3.48)1.75 (0.96-3.17)
    5642.13 (0.57-7.96)1.95 (0.52-7.30)
Ptrend = 0.0001Ptrend = 0.0005
  • * ORs were adjusted for age, race, date of blood draw, history of breast cyst, hormone replacement therapy, and parity.

  • ORs were adjusted for age, race, date of blood draw, history of breast cyst, hormone replacement therapy, parity, and the number of alleles of the opposite type (protective or risk).

  • Protective alleles: CBS rs1801181 (A360A) T and FHTFD rs2002287 (T/C) C.

  • § Risk alleles: MTHFR rs1801133 (C677T) T, MTHFR rs1801131 (A1298C) C, MTHFD1 rs1950902 (R134K) T, and FTHFD rs2276731 (T/C) C.