Table 3.

Association of genotype combinations of the MTHFR C677T and A1298C SNPs with breast cancer

All cases
C677TA1298CNo. cases/controlOR* (95% CI)
CCAA49/761.00 (reference)
CCAC + CC155/1571.53 (0.99-2.38)
CT + TTAA172/1741.56 (1.02-2.40)
CT + TTAC + CC111/822.16 (1.34-3.48)
  • * ORs were calculated using unconditional logistic regression adjusting for age, race, date of blood draw, history of breast cyst, hormone replacement therapy, and parity.