Table 2.

Association of SNPs in folate pathway genes with incidence of breast cancer in all cases and invasive cases

Gene/SNPAll cases
Invasive cases*
No. cases/controlOR (95% CI)No. cases/controlOR (95% CI)
MTHFD1
    rs1950902 (R134K)
        CC316/3531.00241/3531.00
        CT163/1241.49 (1.12-1.99)120/1241.42 (1.04-1.93)
        TT13/160.77 (0.36-1.68)11/160.88 (0.39-1.97)
        CT + TT176/1401.40 (1.06-1.85)131/1401.35 (1.00-1.82)
FTHFD
    rs2276731 (T/C)
        TT317/3441.00250/3441.00
        CT157/1361.23 (0.92-1.63)109/1361.10 (0.81-1.50)
        CC23/132.23 (1.09-4.54)18/132.25 (1.06-4.76)
    rs2002287 (T/C)
        TT220/1881.00172/1881.00
        CT209/2290.76 (0.57-1.00)156/2290.72 (0.54-0.97)
        CC64/770.75 (0.50-1.11)45/770.67 (0.43-1.03)
        CT + CC273/3060.75 (0.58-0.98)201/3060.71 (0.54-0.94)
CBS
    rs1801181 (A360A)
        CC216/1941.00168/1941.00
        CT218/2140.92 (0.70-1.22)161/2140.87 (0.65-1.18)
        TT47/690.63 (0.41-0.96)33/690.56 (0.35-0.91)
MTHFR
    rs1801133 (C677T)
        CC208/2361.00160/2361.00
        CT224/1931.34 (1.02-1.77)167/1931.27 (0.94-1.72)
        TT62/651.09 (0.72-1.63)47/651.06 (0.68-1.64)
        CT + TT286/2581.28 (0.98-1.66)214/2581.22 (0.92-1.61)
    rs1801131 (A1298C)
        AA224/2521.00167/2521.00
        AC228/2011.28 (0.97-1.67)173/2011.31 (0.97-1.75)
        CC42/401.09 (0.67-1.78)35/401.25 (0.75-2.10)
        AC + CC270/2411.25 (0.96-1.62)208/2411.30 (0.98-1.72)
  • * Invasive cases include all but in situ breast cancers.

  • ORs were determined using unconditional logistic regression adjusting for age, race, date of blood draw, history of breast cyst, hormone replacement therapy, and parity.