Relationship of age at diagnosis, number of back nevi, and estimated early-life ambient erythemal UV irradiance to BRAF and NRAS mutational status among melanoma cases (N = 202)
| Characteristic | BRAF+ vs wild-type, OR* (95% CI) | NRAS+ vs wild-type, OR* (95% CI) | ||
|---|---|---|---|---|
| Age at diagnosis (per 10 y) | 0.8 (0.7-1.0) | 1.4 (1.1-1.9) | ||
| No. nevi on the back | ||||
| 0-4 | 1.0 | 1.0 | ||
| 5-14 | 2.8 (1.2-6.4) | 1.1 (0.4-3.3) | ||
| >14 | 3.4 (1.5-7.8) | 1.9 (0.6-5.5) | ||
| Ptrend | 0.004 | 0.27 | ||
| Early-life ambient UV irradiance in kJ/m2/y | ||||
| Low UV (≤770) | 1.0 | 1.0 | ||
| High UV (>770) | 2.6 (1.2-5.6) | 0.9 (0.4-2.2) | ||
NOTE: Subjects were 202 participants for whom no data were missing for the factors in the model.
↵* OR values are adjusted for all factors in the model.