Table 5.

Relationship of age at diagnosis, number of back nevi, and estimated early-life ambient erythemal UV irradiance to BRAF and NRAS mutational status among melanoma cases (N = 202)

CharacteristicBRAF+ vs wild-type, OR* (95% CI)NRAS+ vs wild-type, OR* (95% CI)
Age at diagnosis (per 10 y)0.8 (0.7-1.0)1.4 (1.1-1.9)
No. nevi on the back
    0-41.01.0
    5-142.8 (1.2-6.4)1.1 (0.4-3.3)
    >143.4 (1.5-7.8)1.9 (0.6-5.5)
    Ptrend0.0040.27
Early-life ambient UV irradiance in kJ/m2/y
    Low UV (≤770)1.01.0
    High UV (>770)2.6 (1.2-5.6)0.9 (0.4-2.2)
  • NOTE: Subjects were 202 participants for whom no data were missing for the factors in the model.

  • * OR values are adjusted for all factors in the model.