Table 4.

Indicators of sun exposure by BRAF and NRAS mutational status among melanoma cases (N = 214)

CharacteristicBRAF+ (N = 92)
NRAS+ (N = 29)
Wild-type (N = 93)
BRAF+ vs wild-type, OR* (95% CI)NRAS+ vs wild-type, OR* (95% CI)
n (%)
Anatomic site
    Intermittently exposed site (trunk)54 (59)17 (59)37 (40)1.01.0
    Chronically exposed sites (head/neck/extremities)38 (41)12 (41)56 (60)0.5 (0.3-1.0)0.4 (0.2-0.9)
CSD assessed by histologic solar elastosis
    Non-CSD75 (82)17 (59)59 (63)1.01.0
    CSD17 (18)12 (41)34 (37)0.5 (0.3-1.2)0.7 (0.3-1.9)
Ambient erythemal UV irradiance, annual total in kJ/m2/y
    Lifetime (average of all decadal ages)
        Low UV (≤804)17 (20)9 (33)30 (33)1.01.0
        High UV (>804)70 (80)18 (67)60 (67)2.0 (1.0-4.0)1.1 (0.4-2.7)
    Early life (average of ages 0 and 10 y)
        Low UV (≤770)14 (16)11 (39)30 (33)1.01.0
        High UV (>770)75 (84)17 (61)60 (67)2.6 (1.2-5.3)0.9 (0.4-2.2)
By decade
    Birth year
        Low UV (≤751)17 (19)11 (39)30 (33)1.01.0
        High UV (>751)72 (81)17 (61)60 (67)2.0 (1.0-4.1)0.9 (0.4-2.2)
    Age 10 y
        Low UV (≤804)17 (19)12 (41)29 (32)1.01.0
        High UV (>804)73 (81)17 (59)61 (68)1.9 (1.0-3.9)0.8 (0.3-1.9)
    Age 20 y
        Low UV (≤783)13 (14)12 (41)29 (33)1.01.0
        High UV (>783)77 (86)17 (59)60 (67)2.7 (1.3-5.7)0.8 (0.3-1.9)
    Age 30 y
        Low UV (≤806)25 (31)14 (48)30 (36)1.01.0
        High UV (>806)57 (69)15 (52)53 (64)1.0 (0.5-1.9)0.7 (0.3-1.8)
    Age 40 y
        Low UV (≤806)14 (22)9 (31)25 (34)1.01.0
        High UV (>806)49 (78)20 (69)48 (66)1.4 (0.6-3.3)1.3 (0.5-3.4)
    Age 50 y
        Low UV (≤806)8 (18)5 (19)20 (38)1.01.0
        High UV (>806)37 (82)21 (81)32 (62)1.2 (0.4-3.8)2.5 (0.7-8.5)
    Age 60 y
        Low UV (≤807)3 (17)4 (25)14 (38)1.01.0
        High UV (>807)15 (83)12 (75)23 (62)1.1 (0.2-7.0)2.0 (0.4-9.8)
  • * OR values are adjusted for age as a continuous variable.

  • Counts may not sum to the total number of study subjects due to missing data.

  • Logistic regression models above age 60 y were unstable due to sparse data.