Phenotypic characteristics by BRAF and NRAS mutational status among melanoma cases (N = 214)
Characteristic | BRAF+ (N = 92) | NRAS+ (N = 29) | Wild-type (N = 93) | BRAF+ vs wild-type, OR* (95% CI) | NRAS+ vs wild-type, OR* (95% CI) | |||||
---|---|---|---|---|---|---|---|---|---|---|
n† (%) | ||||||||||
No. nevi on the back | ||||||||||
Median (interquartile range) | 14.5 (7-34) | 12.0 (4-20) | 9.0 (3-19) | |||||||
0-4 | 14 (16) | 9 (31) | 32 (36) | 1.0 | 1.0 | |||||
5-14 | 31 (34) | 9 (31) | 28 (31) | 2.4 (1.1-5.5) | 1.2 (0.4-3.7) | |||||
>14 | 45 (50) | 11 (38) | 29 (33) | 3.2 (1.4-7.0) | 1.7 (0.6-4.8) | |||||
Ptrend | 0.006 | 0.34 | ||||||||
Nevus density diagrams | ||||||||||
None | 11 (12) | 5 (19) | 27 (30) | 1.0 | 1.0 | |||||
Low | 51 (58) | 17 (62) | 49 (55) | 2.3 (1.0-5.2) | 2.7 (0.8-8.6) | |||||
Medium to high | 26 (30) | 5 (19) | 13 (15) | 3.8 (1.4-10.4) | 3.3 (0.7-14.9) | |||||
Ptrend | 0.009 | 0.10 | ||||||||
Propensity to tan | ||||||||||
Deep tan | 20 (23) | 5 (19) | 11 (13) | 1.0 | 1.0 | |||||
Moderate tan | 34 (38) | 13 (48) | 35 (41) | 0.5 (0.2-1.3) | 0.7 (0.2-2.6) | |||||
Mild tan | 27 (31) | 6 (22) | 24 (28) | 0.7 (0.3-1.8) | 0.4 (0.1-1.8) | |||||
No tan | 7 (8) | 3 (11) | 15 (18) | 0.3 (0.1-0.9) | 0.3 (0.1-1.6) | |||||
Ptrend | 0.13 | 0.09 | ||||||||
Childhood freckles | ||||||||||
None | 50 (56) | 13 (45) | 48 (52) | 1.0 | 1.0 | |||||
Few | 31 (34) | 14 (48) | 29 (31) | 0.9 (0.5-1.8) | 2.0 (0.8-4.8) | |||||
Many | 9 (10) | 2 (7) | 16 (17) | 0.5 (0.2-1.2) | 0.5 (0.1-2.4) | |||||
Ptrend | 0.18 | 0.92 | ||||||||
Hair color | ||||||||||
Black or dark brown | 28 (30) | 12 (41) | 28 (30) | 1.0 | 1.0 | |||||
Light brown or blond | 57 (62) | 13 (45) | 50 (54) | 1.2 (0.6-2.3) | 0.6 (0.2-1.4) | |||||
Red | 7 (8) | 4 (14) | 14 (15) | 0.5 (0.2-1.5) | 0.6 (0.2-2.4) | |||||
Eye color | ||||||||||
Black or brown | 26 (28) | 7 (24) | 26 (28) | 1.0 | 1.0 | |||||
Hazel, green, gray or blue | 66 (72) | 22 (76) | 67 (72) | 1.0 (0.5-2.0) | 1.3 (0.5-3.4) |