Table 1.

Spectrum of BRAF and NRAS mutations in invasive cutaneous melanomas (N = 214)

GeneMutationBase changeNo. patients%*
BRAFV600EGTG to GAG6028.0
V600KGTG to AAG157.0
V600EGTG to GAA41.9
V600RGTG to AGG20.9
V600DGTG to GAT10.5
VKS600-602DTGTG-AAA-TCT to GAT-ACT10.5
K601EAAA to GAA20.9
K601NAAA to AAC10.5
L597RCTA to CGA10.5
D594NGAT to AAT10.5
G469AGGA to GCA10.5
G466EGGA to GAA10.5
G455RGGG to AGG10.5
G455EGGG to GAG10.5
NRASQ61KCAA to AAA146.5
Q61RCAA to CGA104.7
Q61LCAA to CTA41.9
Q61HCAA to CAC10.5
  • * Percentage of melanomas screened that carry this alteration.

  • A deletion of six bases and an insertion of three bases, with a net loss of three bases. Wild-type residue 603/Arg would then follow the Asp-Thr.