Haseman-Elston regression under the following conditions | ||||||||||||||||||||||||
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Marker | (a) Original estimates* | (b) Including TBFBR1 genotypes^{†} | (c) Including TGFBR1*6A alleles (0, 1, 2, 3, or 4) as a pair-specific covariate at D9S1786 | |||||||||||||||||||||

β^{‡} | SE^{§} | P | β | SE | P | β for D9S1786 | SE | P | β for the covariate^{‡} | SE | P | |||||||||||||

D9S283 | 0.1584 | 0.0583 | 0.0036 | 0.1584 | 0.0585 | 0.003 | NA | NA | NA | NA | NA | NA | ||||||||||||

D9S1786 | 0.1796 | 0.0539 | 0.0005 | 0.1684 | 0.0552 | 0.001 | 0.1784 | 0.0559 | 0.0008 | 0.0032 | 0.0271 | 0.906 | ||||||||||||

TGFBR1^{∥} | 0.1772 | 0.0554 | 0.0008 | 0.1297 | 0.0557 | 0.012 | NA | NA | NA | NA | NA | NA |

NOTE: (

*a*) original multipoint identical by descent estimates without the*TGFBR1*6A*and*TGFBR1*9A*genotypes. (*b*) multipoint identical by descent estimates with the*TGFBR1*6A*and*TGFBR1*9A*genotypes. (*c*) regression analysis including*TGFBR1*6A*alleles as a covariate.Abbreviation: NA, not available.

↵* Analysis included the 17 polymorphic markers used in the original linkage study of this region to estimate the Haseman-Elston regression coefficient

*β*.↵† Analysis using the original 17 polymorphic and the

*TBFBR1*6A*and*9A*genotypes to estimate*β*(7).↵‡ The Haseman-Elston regression coefficient

*β*estimates the amount of trait variation due to a gene at this location. The covariate regression coefficient*β*in (*c*) estimates the effect of the number of*TBFBR1*6A*alleles from 0 to 4 that are carried by a pair of sibs on being affected.↵§ SE associated with the estimate of

*β*.↵∥ The allele sharing for

*TGFBR1*is interpolated based upon the allele sharing at the 17 polymorphic markers but does not actually use the*TGFBR1*genotypes in the original estimates.