Associations between haplotyes of CYP19A1 and endometrial cancer risk
| Haplotypes | All subjects | Premenopausal women | Postmenopausal women | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR* (95% CI) | Cases | Controls | OR* (95% CI) | Cases | Controls | OR* (95% CI) | |||||||
| GCACA† | 588 | 550 | 1.0 | 256 | 211 | 1.0 | 332 | 339 | 1.0 | ||||||
| TCATC | 296 | 367 | 0.76 (0.62-0.92) | 126 | 134 | 0.79 (0.58-1.07) | 170 | 233 | 0.75 (0.58-0.96) | ||||||
| GCCTA | 373 | 331 | 1.05 (0.87-1.27) | 161 | 124 | 1.07 (0.79-1.44) | 212 | 207 | 1.05 (0.82-1.34) | ||||||
| TTCTA | 193 | 166 | 1.09 (0.89-1.38) | 84 | 62 | 1.11 (0.76-1.62) | 109 | 104 | 1.07 (0.79-1.46) | ||||||
| GCATC | 150 | 168 | 0.83 (0.65-1.07) | 61 | 80 | 0.64 (0.44-0.93) | 89 | 88 | 1.04 (0.74-1.44) | ||||||
| TCACA | 183 | 173 | 0.99 (0.78-1.26) | 89 | 67 | 1.06 (0.74-1.54) | 94 | 106 | 0.91 (0.66-1.24) | ||||||
| Others | 301 | 315 | 0.90 (0.74-1.09) | 125 | 114 | 0.90 (0.66-1.23) | 176 | 201 | 0.89 (0.69-1.15) | ||||||
| Ptrend | 0.75 | 0.64 | 0.88 | ||||||||||||
NOTE: The number of participants does not add up to the total number of women because of missing data on genotypes for some participants.
↵* Unconditional logistic model adjusted for age.
↵† In the order of SNP 1-2-3-4-5 based on their chromosome position (SNP1, rs1065779; SNP2, rs700519; SNP3, rs28566535; SNP4, rs752760; and SNP5, rs1870050).