Associations between CYP19A1 genotypes and endometrial cancer risk among postmenopausal women
| BMI < 25 | BMI ≥ 25 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR* (95% CI) | Cases | Controls | OR* (95% CI) | |||||||
| rs1065779 | ||||||||||||
| G/G | 91 | 113 | 1.0 | 100 | 79 | 1.0 | ||||||
| G/T | 129 | 181 | 0.92 (0.67-1.25) | 176 | 124 | 1.17 (0.84-1.62) | ||||||
| T/T | 40 | 91 | 0.57 (0.37-0.87) | 52 | 50 | 0.86 (0.54-1.35) | ||||||
| Ptrend | 0.02 | 0.47 | ||||||||||
| Pinteraction = 0.27 | ||||||||||||
| rs700519 | ||||||||||||
| C/C | 210 | 286 | 1.0 | 225 | 188 | 1.0 | ||||||
| C/T | 47 | 89 | 0.72 (0.49-1.06) | 88 | 56 | 1.32 (0.91-1.92) | ||||||
| T/T | 2 | 10 | 0.28 (0.06-1.27) | 7 | 4 | 1.46 (0.42-5.06) | ||||||
| Ptrend | 0.03 | 0.15 | ||||||||||
| Pinteraction = 0.01 | ||||||||||||
| rs28566535 | ||||||||||||
| A/A | 121 | 174 | 1.0 | 128 | 106 | 1.0 | ||||||
| A/C | 116 | 165 | 0.99 (0.73-1.35) | 154 | 114 | 1.16 (0.84-1.60) | ||||||
| C/C | 25 | 48 | 0.74 (0.44-1.24) | 45 | 29 | 1.34 (0.80-2.23) | ||||||
| Ptrend | 0.45 | 0.34 | ||||||||||
| Pinteraction = 0.22 | ||||||||||||
| rs752760 | ||||||||||||
| T/T | 86 | 138 | 1.0 | 126 | 105 | 1.0 | ||||||
| T/C | 137 | 183 | 1.1 7 (0.87-1.60) | 154 | 94 | 1.47 (1.05-2.04) | ||||||
| C/C | 36 | 53 | 1.07 (0.67-1.59) | 42 | 40 | 0.94 (0.58-1.52) | ||||||
| Ptrend | 0.53 | 0.85 | ||||||||||
| Pinteraction = 0.76 | ||||||||||||
| rs1870050 | ||||||||||||
| A/A | 141 | 177 | 1.0 | 176 | 119 | 1.0 | ||||||
| A/C | 97 | 169 | 0.73 (0.54-1.00) | 126 | 103 | 0.92 (0.66-1.27) | ||||||
| C/C | 17 | 35 | 0.62 (0.34-1.14) | 20 | 21 | 0.71 (0.38-1.36) | ||||||
| Ptrend | 0.03 | 0.13 | ||||||||||
| Pinteraction = 0.69 | ||||||||||||
NOTE: The number of participants does not add up to the total number of women because of missing data on genotypes for some participants.
↵* Unconditional logistic model adjusted for age.