Table 3.

Associations between CYP19A1 genotypes and endometrial cancer risk

All subjects
Premenopausal women
Postmenopausal women
CasesControlsOR* (95% CI)CasesControlsOR* (95% CI)CasesControlsOR* (95% CI)
rs1065779(n = 1,033)(n = 1,030)
    G/G3303171.01391281.01911891.0
    G/T5324951.07 (0.90-1.27)2271901.08 (0.82-1.43)3053051.04 (0.84-1.31)
    T/T1712180.78 (0.62-0.99)79770.94 (0.65-1.37)921410.68 (0.50-0.93)
    Ptrend0.060.910.02
    Pinteraction = 0.15
rs700519(n = 1,025)(n = 1,026)
    C/C7737741.03383001.04354741.0
    C/T2372321.03 (0.84-1.26)102871.05 (0.76-1.44)1351451.01 (0.78-1.31)
    T/T15200.76 (0.39-1.49)660.92 (0.29-2.90)9140.70 (0.30-1.62)
    Ptrend0.840.910.74
    Pinteraction = 0.73
rs28566535(n = 1,040)(n = 1,031)
    A/A4364521.01871721.02492801.0
    A/C4784701.08 (0.90-1.27)2081911.03 (0.78-1.34)2702791.10 (0.88-1.36)
    C/C1261091.22 (0.92-1.61)56321.62 (1.01-2.60)70771.03 (0.72-1.46)
    Ptrend0.240.160.69
    Pinteraction = 0.40
rs752760(n = 1,027)(n = 995)
    T/T3653911.01531481.02122431.0
    T/C5084481.27 (1.07-1.51)2171711.29 (0.98-1.71)2912771.25 (1.00-1.55)
    C/C1541561.11 (0.86-1.42)76631.18 (0.80-1.74)78931.00 (0.71-1.39)
    Ptrend0.320.380.72
    Pinteraction = 0.62
rs1870050(n = 1,015)(n = 1,007)
    A/A5664781.02491821.03172961.0
    A/C3834260.81 (0.68-0.97)1601540.85 (0.64-1.12)2232720.81 (0.65-1.01)
    C/C661030.58 (0.42-0.80)29470.49 (0.30-0.81)37560.65 (0.42-1.01)
    Ptrend<0.01<0.010.01
    Pinteraction = 0.54
  • NOTE: The number of participants does not add up to the total number of women because of missing data on genotypes for some participants.

  • * Unconditional logistic model adjusted for age.