Allele frequencies (%) of the CYP19A1 gene and haplotype distribution of CYP19A1 polymorphisms, the Shanghai Endometrial Cancer Study
| Alleles | Cases (%) | P (HWE) | Controls (%) | P (HWE) | P | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | ||||||||||
| rs1065779 | ||||||||||
| G | 1,192 (57.7) | 0.08 | 1,129 (54.8) | 0.34 | 0.06 | |||||
| T | 874 (42.3) | 931 (45.2) | ||||||||
| rs700519 | ||||||||||
| C | 1,783 (87.0) | 0.51 | 1,780 (86.7) | 0.60 | 0.83 | |||||
| T | 267 (13.0) | 272 (13.3) | ||||||||
| rs28566535 | ||||||||||
| A | 1,350 (64.9) | 0.77 | 1,374 (66.6) | 0.42 | 0.24 | |||||
| C | 730 (35.1) | 688 (33.4) | ||||||||
| rs752760 | ||||||||||
| T | 1,238 (60.3) | 0.29 | 1,230 (61.8) | 0.14 | 0.32 | |||||
| C | 816 (39.7) | 760 (38.2) | ||||||||
| rs1870050 | ||||||||||
| A | 1,515 (74.6) | 0.91 | 1,382 (68.6) | 0.57 | <0.01 | |||||
| C | 515 (25.4) | 632 (31.4) | ||||||||
| Estimated frequency of CYP19A1 haplotypes (in the order of SNP 1-2-3-4-5* based on their chromosome positions) | ||||||||||
| GCACA | 27.8 | 26.2 | ||||||||
| TCATC | 12.3 | 15.6 | ||||||||
| GCCTA | 16.0 | 14.0 | ||||||||
| TTCTA | 8.8 | 7.6 | ||||||||
| GCATC | 8.8 | 9.6 | ||||||||
| TCACA | 8.5 | 8.3 | ||||||||
| Others | 18.5 | 17.7 | ||||||||
| Overall χ2 test | P = 0.02 | |||||||||
NOTE: The number of participants does not add up to the total number of women because of missing data on genotypes for some participants. Common allele of the SNP is in boldface type.
↵* SNP1, rs1065779; SNP2, rs700519; SNP3, rs28566535; SNP4, rs752760; and SNP5, rs1870050.