Table 2.

Allele frequencies (%) of the CYP19A1 gene and haplotype distribution of CYP19A1 polymorphisms, the Shanghai Endometrial Cancer Study

AllelesCases (%)P (HWE)Controls (%)P (HWE)P
SNP
    rs1065779
        G1,192 (57.7)0.081,129 (54.8)0.340.06
        T874 (42.3)931 (45.2)
    rs700519
        C1,783 (87.0)0.511,780 (86.7)0.600.83
        T267 (13.0)272 (13.3)
    rs28566535
        A1,350 (64.9)0.771,374 (66.6)0.420.24
        C730 (35.1)688 (33.4)
    rs752760
        T1,238 (60.3)0.291,230 (61.8)0.140.32
        C816 (39.7)760 (38.2)
    rs1870050
        A1,515 (74.6)0.911,382 (68.6)0.57<0.01
        C515 (25.4)632 (31.4)
Estimated frequency of CYP19A1 haplotypes (in the order of SNP 1-2-3-4-5* based on their chromosome positions)
    GCACA27.826.2
    TCATC12.315.6
    GCCTA16.014.0
    TTCTA8.87.6
    GCATC8.89.6
    TCACA8.58.3
    Others18.517.7
    Overall χ2 testP = 0.02
  • NOTE: The number of participants does not add up to the total number of women because of missing data on genotypes for some participants. Common allele of the SNP is in boldface type.

  • * SNP1, rs1065779; SNP2, rs700519; SNP3, rs28566535; SNP4, rs752760; and SNP5, rs1870050.