Table 1.

Variance components for assays of IGF-I and IGFBP-3 from run-in and main study

(A) Variance components
Source*IGFBP-3
Ln IGF-1
Run-inMain studyRun-inMain study
Between-subject891,683834,3530.08610.0884
Between-week259,21700.00110.0006
Between-day24,6177,6270.00120.0040
Between-plate89,17650,6830.00350.0054
Within-subject122,57174,8490.01500.0133
(B) Percent of variance associated with different factors
Source*IGFBP-3
Ln IGF-1

Run-in
Main study
Run-in
Main study
Between-subject64.386.280.582.7
Between-week18.701.00.6
Between-day1.80.81.13.7
Between-plate6.45.23.35.0
Within-subject8.814.014.012.4
  • NOTE: Day is nested in week and plate is nested in day and week.

  • * Variance estimates obtained with restricted maximum likelihood approach.