Table 6.

IL6 haplotype interaction with aspirin use and breast cancer risk in the 4-Corner's Study

Haplotype
Postmenopausal, recent hormone exposure
Postmenopausal, no recent hormone exposure
AGGGCOR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
0 Copy1 Copy2 Copies0 Copy1 Copy2 Copies
Non-Hispanic white
    Aspirin useNo1.001.17 (0.96-1.43)1.38 (0.92-2.05)1.001.15 (0.85-1.56)1.33 (0.73-2.42)
Yes0.79 (0.50-1.25)0.87 (0.63-1.21)0.95 (0.61-1.49)1.06 (0.54-2.05)1.23 (0.75-2.03)1.45 (0.74-2.83)
        P interaction0.720.95
Hispanic/Native American
    Aspirin useNo1.001.32 (0.98-1.78)1.74 (0.96-3.15)1.001.56 (1.06-2.31)2.45 (1.13-5.32)
Yes1.64 (0.78-3.43)1.12 (0.66-1.92)0.77 (0.33-1.78)0.68 (0.23-2.00)0.95 (0.46-1.96)1.34 (0.48-3.73)
        P interaction0.050.81
GGCAC
Non-Hispanic white
    Aspirin useNo1.000.87 (0.71-1.06)0.75 (0.50-1.13)1.000.76 (0.56-1.04)0.58 (0.32-1.08)
Yes0.76 (0.51-1.14)0.64 (0.46-0.88)0.53 (0.32-0.88)0.96 (0.54-1.71)0.84 (0.53-1.34)0.74 (0.37-1.47)
        P interaction0.830.62
Hispanic/Native American
    Aspirin useNo1.001.05 (0.73-1.51)1.10 (0.54-2.27)1.000.69 (0.42-1.13)0.48 (0.18-1.28)
Yes0.82 (0.48-1.40)1.16 (0.58-2.31)1.64 (0.43-6.19)0.63 (0.31-1.26)0.36 (0.13-1.01)0.21 (0.03-1.66)
        P interaction0.480.78
ACGGC
Non-Hispanic white
    Aspirin useNo1.001.06 (0.69-1.63)1.12 (0.47-2.67)1.001.61 (0.87-2.97)2.58 (0.75-8.84)
Yes0.70 (0.53-0.94)1.21 (0.62-2.33)2.07 (0.56-7.68)1.23 (0.81-1.86)0.64 (0.24-1.68)0.33 (0.05-2.26)
        P interaction0.240.06
Hispanic/Native American
    Aspirin useNo1.000.69 (0.50-0.97)0.48 (0.25-0.94)1.000.84 (0.53-1.32)0.71 (0.29-1.75)
Yes0.60 (0.33-1.10)0.88 (0.51-1.51)1.27 (0.47-3.42)0.44 (0.21-0.95)0.72 (0.33-0.58)1.17 (0.26-5.27)
        P interaction0.040.20
  • NOTE: ORs and 95% CIs adjusted for age, study center, referent year BMI, lifetime physical activity score, parity, and percentage Native American ancestry. Labeling indicates base at each of five SNPs in order of chromosomal location: rs1800797, rs1800796, rs1800795, rs2069832, and rs2069849.