Table 5.

Interaction of regular aspirin use and IL6 rs1800796 postmenopausal women in the 4-Corner's Study

Non-Hispanic white
Hispanic/Native American
rs1800796 GG
rs1800796 GC/CC
rs1800796 GG
rs1800796 GC/CC
Cases, nControls, nOR (95% CI)Cases, nControls, nOR (95% CI)Cases, nControls, nOR (95% CI)Cases, nControls, nOR (95% CI)
Postmenopausal women, recent hormone exposure
AspirinNo3623741.0042430.98 (0.62-1.55)1021061.00661030.68 (0.44-1.03)
useYes1091630.71 (0.53-0.95)20181.14 (0.59-2.21)19390.55 (0.30-1.04)24270.97 (0.52-1.81)
P interaction0.240.04
Postmenopausal women, no recent hormone exposure
AspirinNo1311961.0024241.83 (0.97-3.45)66731.0036640.58 (0.33-1.01)
useYes60771.22 (0.80-1.86)6140.68 (0.24-1.86)11320.37 (0.17-0.82)11160.77 (0.32-1.84)
P interaction0.060.04
  • NOTE: ORs and 95% CIs adjusted for age, study center, referent year BMI, lifetime physical activity score, parity, and percentage Native American ancestry.