Table 4.

Association with aspirin and NSAID use and breast cancer in the 4-Corner's Study

Non-Hispanic white
Hispanic/Native American
Controls, n (%)Cases, n (%)OR (95% CI)1Controls, n (%)Cases, n (%)OR (95% CI)
Premenopausal/perimenopausal
    Aspirin use
        No426 (86.9)445 (83.2)1.00299 (90.6)303 (92.1)1.00
        Yes64 (13.1)90 (16.8)1.32 (0.92-1.89)31 (9.4)26 (7.9)0.87 (0.50-1.53)
    NSAID use
        No357 (72.7)393 (73.5)1.00246 (74.5)258 (78.4)1.00
        Yes134 (27.3)142 (26.5)0.96 (0.73-1.28)84 (25.5)71 (21.6)0.87 (0.60-1.27)
Postmenopausal with no recent hormone exposure
    Aspirin use
        No273 (71.5)187 (68.5)1.00181 (75.1)153 (84.5)1.00
        Yes109 (28.5)86 (31.5)1.14 (0.80-1.62)60 (24.9)28 (15.5)0.56 (0.33-0.96)
    NSAID use
        No286 (74.7)204 (74.7)1.00184 (76.3)146 (80.7)1.00
        Yes97 (25.3)69 (25.3)0.95 (0.65-1.38)57 (23.7)35 (19.3)0.80 (0.48-1.34)
Postmenopausal with recent hormone exposure
    Aspirin use
        No492 (69.8)516 (74.2)1.00250 (75.8)217 (80.1)1.00
        Yes213 (30.2)179 (25.8)0.82 (0.64-1.04)80 (24.2)54 (19.9)0.86 (0.57-1.30)
    NSAID use
        No456 (64.8)455 (65.5)1.00221 (67.0)197 (72.7)1.00
        Yes248 (35.2)240 (34.5)1.03 (0.82-1.29)109 (33.0)74 (27.3)0.80 (0.56-1.15)
  • NOTE: “Yes” represents any regular use (at least thrice weekly for at least 1 mo). ORs and 95% CIs adjusted for age, study center, referent year BMI, lifetime physical activity score, parity, and percentage Native American ancestry.