Table 2.

Frequencies of five IL6 SNPs and haplotypes in 4-Corner's Study controls

Marker*GenotypeSelf-reported race/ethnicity
Hispanic/Native American, by tertile of percentage of Native American ancestry
Non-Hispanic white (n = 1,329)
Hispanic/Native American (n = 726)
Low (n = 247)
Intermediate (n = 234)
High (n = 245)
Frequency (%)P HWEFrequency (%)P HWEFrequency (%)P HWEFrequency (%)P HWEFrequency (%)P HWE
rs1800797AA32.364.662.061.170.6
(−596A>G)AG49.032.233.135.528.2
GG18.83.24.93.41.2
MAF43.20.9419.30.3521.40.7821.20.3315.30.18
rs1800796GG89.455.964.052.651.0
(−572G>C)GC10.336.930.041.539.6
CC0.37.26.16.09.4
MAF5.50.9825.60.4021.10.1226.70.3729.20.51
rs1800795GG30.863.460.360.369.4
(−174G>C)GC49.732.934.835.528.6
CC19.53.74.94.32.0
MAF44.40.7820.20.5522.30.9322.00.6116.30.47
rs2069832, G>AGG30.763.059.960.368.6
intron 2GA49.933.234.835.529.4
AA19.53.95.34.32.0
MAF44.40.7320.50.5922.70.9122.00.6116.70.39
rs2069849,CC95.687.290.785.884.8
exon 5 C/TCT4.412.68.913.715.2
TT0.10.30.40.40.0
MAF2.30.696.60.504.80.567.30.827.60.20
HaplotypesAGGGC47.747.552.044.046.9
GGCAC42.719.121.520.815.2
ACGGC5.325.420.426.428.9
AGGGT2.16.64.97.37.6
  • Abbreviation: HWE, Hardy-Weinberg equilibrium.

  • * IL6 gene region: rs1800797, rs1800796, and rs1800795, 5′ promoter; rs2069832, intron 2; rs2069849, coding exon 5.

  • Mantel-Haenszel χ2 test, genotype, and self-reported race (P < 0.0001 for all SNPs genotype) and percentage Native American ancestry categories (P < 0.0001 for all SNPs).

  • Log likelihood omnibus test (28), haplotype distribution, and self-reported race (P < 0.0001) and percentage Native American ancestry (lowest versus highest tertile; P < 0.01).