Table 3.

Risk of breast cancer (HR) associated with type and age of menopause

Whole cohort
BRCA1 carriers
BRCA2 carriers
Pyrs*BCHR (95% CI)HR (95% CI)HR (95% CI)
Menopausal status
    Premenopause57,459665111
    Postmenopause1,8571100.97 (0.68-1.39)1.01 (0.68-1.49)0.51 (0.21-1.22)
    Unknown6,359780.87 (0.61-1.22)0.85 (0.59-1.24)0.75 (0.30-1.88)
Type of menopause
    Oophorectomy420170.56 (0.29-1.09)0.50 (0.24-1.04)0.40 (0.07-2.44)
    Natural1,200781.03 (0.67-1.59)1.17 (0.73-1.90)0.60 (0.21-1.73)
    Other type237151.71 (1.04-2.81)1.84 (1.20-2.82)0.24 (0.03-2.11)
Age at menopause
    Premenopause57,459665111
        <3527480.60 (0.25-1.44)0.50 (0.21-1.21)∼0 (—)
        35-44525361.02 (0.65-2.04)1.41 (0.72-2.79)0.79 (0.28-2.21)
        45-541,000621.15 (0.65-1.60)1.08 (0.66-1.77)0.39 (0.12-1.26)
        ≥555841.12 (0.25-5.02)2.47 (0.54-11.2)∼0 (—)
    Unknown6,359780.88 (0.63-1.25)0.87 (0.60-1.27)0.73 (0.29-1.84)
Type of menopause and age at oophorectomy
    Premenopause57,459665111
    Oophorectomy
        <3514010.07 (0.01-0.57)0.05 (0.01-0.49)∼0 (—)
        35-44140111.17 (0.43-3.22)0.90 (0.27-3.01)4.19 (1.53-11.5)
        ≥4514050.57 (0.24-1.38)0.80 (0.36-1.76)∼0 (—)
    Postmenopausal, natural1,200781.03 (0.67-1.59)1.19 (0.74-1.93)0.51 (0.18-1.49)
    Postmenopausal, other type237151.71 (1.04-2.81)1.84 (1.21-2.81)0.25 (0.03-2.24)
    Unknown6,359780.87 (0.62-1.23)0.86 (0.60-1.25)0.67 (0.27-1.68)
Time since oophorectomy
    Premenopause57,459665111
        ≤1 y5530.84 (0.23-3.04)0.98 (0.26-3.73)∼0
        2-3 y7930.61 (0.21-1.74)0.68 (0.25-1.88)∼0
        ≥4 y289110.49 (0.21-1.16)0.37 (0.14-1.00)0.77 (0.08-7.07)
Type of menopause and age at natural menopause
    Premenopause57,459665111
    Postmenopausal, natural
        <45332200.94 (0.44-2.04)1.49 (0.56-3.97)0.64 (0.19-2.18)
        45-54810541.09 (0.66-1.78)1.03 (0.60-1.79)0.61 (0.16-2.29)
        ≥555841.04 (0.23-4.79)2.24 (0.46-10.9)∼0 (—)
    Postmenopausal, oophorectomy420170.57 (0.29-1.09)0.50 (0.24-1.04)0.39 (0.06-2.38)
    Postmenopausal, other type237151.71 (1.04-2.81)1.83 (1.19-2.81)0.24 (0.03-2.11)
    Unknown6,359780.87 (0.62-1.23)0.85 (0.59-1.24)0.75 (0.30-1.88
Time since natural menopause
    Premenopause57,459665111
        <5 y594360.98 (0.60-1.60)1.05 (0.60-1.85)0.66 (0.20-2.11)
        5-9 y275171.02 (0.50-2.11)1.45 (0.60-3.49)0.54 (0.15-1.90)
        >9 y331251.26 (0.60-2.65)1.51 (0.55-4.09)0.54 (0.12-2.52)
  • * Number of person-years of observation in the specified cohort.

  • Number of breast cancer cases occurring in the specified cohort.

  • Estimated hazard ratio, stratified by birth cohort and country group and adjusted for number of children and HRT use.